Spatial Transcriptomics
Map gene expression using
Spatial Transcriptomics
Admera offers whole transcriptome spatial profiling and spatial biology services utilizing cutting-edge digital spatial profiling technologies including Visium HD, stereo-seq, and Curio.
CERTIFIED PROVIDER
Annual Recertifications10X Genomics
STOmics
Curio
WHY SPATIAL TRANSCRIPTOMICS
Gene Expression With Tissue Architecture
Spatial transcriptomics adds a crucial layer of information to traditional single-cell sequencing. Single-cell sequencing identifies cell types and gene expression within a tissue. Spatial transcriptomics then maps where those cells are located and how their gene expression changes across space.
In addition to revealing what cell types are present, spatial omics reveal how they are organized and how their surrounding cells influence their gene expression. Combined with single-cell data, this places detailed molecular information directly within the broader tissue architecture providing a complete picture of tissue biology.
Your Samples are Ready. Is Your Shipment?
Learn which platform fits your tissue type, the right quality metrics, and how to pack and ship for a seamless submission.
Trusted Providers & Certified Services with Our Lab
Gain spatial insights with high sensitivity & accuracy from fixed sample types
Visium HD
CytAssist-powered workflow provides high-definition, whole transcriptome gene expression to study spatial biology with continuous coverage
Compatible with fresh frozen, PFA-fixed, and FFPE tissue
Don’t see the platform you want to use? Contact us.
Explore spatial biology at true-single-cell resolution for advanced precision
Stereo-seq: Species-agnostic workflow achieves high resolution for unprecedented field-of-view of tissue, cellular, subcellular, and molecular-level analysis FF/Fixed F tissues
Stereo-seq OMNI: utilize Stereo-seq technology to gain spatial information from FFPE samples
Don’t see the platform you want to use? Contact us.
COMPATIBILITY
Platform Features
Check your sample type against our full platform matrix before submitting a quote request.
END-TO-END WORKFLOW
From Tissue Section to Spatial Insights
Check your sample type against our full platform matrix before submitting a quote request.
1
Consultation
All projects begin with an expert scientific consultation to align on project goals, species, disease model, sample type, and spatial transcriptomics platform selection.
We support 10X Genomics and STOmics platforms across human, mouse, monkey, and other species.
2
Sample preparation
Proper sample preparation is essential to preserving tissue integrity and ensuring high-quality spatial data. We provide platform-specific guidance for fresh frozen, FFPE, and other intact tissue sample types, including optimal sectioning and handling protocols.
3
Sample QC
Our fully equipped histology lab handles all tissue collection and preservation, sectioning, staining, and microscopic analysis of intact tissue samples. We support fresh frozen, fixed frozen, and FFPE sample types across a wide range of tissue types.
4
Library Preparation & Sequencing
Libraries are prepared using platform-specific protocols with spatial barcode capture and sequenced via next-generation sequencing to the appropriate depth for comprehensive spatial gene expression coverage. For all different sample types, optional 10x Gem-X Flex single cell RNA sequencing is available alongside your spatial data.
5
Data Analysis
Data is processed using Visium HD Space Ranger and visualized in the Loupe Browser for annotation and clustering, spatially resolved transcriptomic pattern visualization, and custom marker gene annotation at single cell resolution. All projects are delivered within 2–3 weeks.
GETTING STARTED
Frequently Asked Questions
Sending samples?
See our spatial sample submission guidelines for best practices on sample preparation, packaging, and shipment for the highest quality results.
-
Spatial transcriptomics maps gene expression to precise tissue locations, adding further context to single-cell data.
While single-cell sequencing reveals cellular diversity and molecular profiles, spatial transcriptomics shows where those cells reside and how their gene expression changes across the tissue landscape.
This powerful approach allows researchers to explore how spatial organization, microenvironments, and cell-to-cell interactions influence gene activity. When combined with single-cell analysis, it enables a comprehensive, high-resolution view of biology connecting molecular detail to tissue structure for deeper insights into health and disease.
-
Spatial transcriptomics maps gene expression to precise tissue locations, revealing how gene activity changes across the tissue landscape. It allows researchers to explore how spatial organization, microenvironments, and cell-to-cell interactions influence gene activity insights that single-cell sequencing alone cannot provide.
-
Spatial transcriptomics supports research across four key areas.
In embryonic development, it reveals dynamic gene activity during embryogenesis and organogenesis. In neuroscience, it maps gene expression to understand neurodegenerative diseases, neurological disorders, brain development, and aging at cellular resolution.
In immunology, it spatially resolves immune cell infiltration, phenotypes, and cell-cell interactions within tissues. In oncology, it maps tumor heterogeneity, tumor microenvironment composition, and cell-cell interactions to identify drug targets, predict treatment response and resistance, and understand cancer progression in situ.
-
The field has advanced to offer technologies that capture gene expression at the tissue, cellular, subcellular, and molecular level.
Visium HD provides high-definition whole transcriptome gene expression with continuous coverage at single-cell resolution.
Stereo-seq achieves high resolution for an unprecedented field of view. Stereo-seq OMNI extends this to FFPE samples, and Curio Trekker delivers unbiased whole transcriptome spatial gene expression for fresh-frozen tissue as well as FFPE using Slide tags technology.
Understanding spatial transcriptomics
Sample & sequencing recommendations/requirements
-
Our team has extensive experience working with a variety of sample and tissue types, including FFPE and frozen tissues.
-
Visium HD is compatible with fresh frozen, PFA-fixed, and FFPE tissue and provides high-definition whole transcriptome coverage using a CytAssist-powered workflow. Stereo-seq is a species-agnostic workflow for fresh frozen tissue offering an unprecedented field of view at subcellular and molecular resolution. Stereo-seq OMNI uses that same technology for FFPE samples. Curio Seeker is designed for fresh-frozen tissue using Slide-seq technology, and Curio Trekker converts existing single-cell data into spatial data using Slide-tag technology without requiring new tissue sections, also compatible with FFPE samples.
-
Spatial omics requires working with a variety of sample and tissue types under demanding conditions. Optimized protocols support ultra-low input and challenging samples, including FFPE and frozen tissues. Admera Health holds Certified Service Provider status for its spatial platforms and maintains CAP accreditation and CLIA licensing to ensure high-quality results across diverse project types.
-
Our team of expert bioinformaticians curates pipelines tailored to your project's experimental design to help you get the most out of your spatial gene expression data. Admera Health provides comprehensive support for each phase of your project, from sample submission through sequencing and advanced data analysis.
-
Yes. Spatial transcriptomics and single-cell sequencing complement each other directly. Spatial transcriptomics shows where cells reside and how gene expression changes across the tissue landscape, while single-cell sequencing reveals cellular diversity and molecular profiles. Curio Trekker is specifically designed to convert existing single-cell data into spatial data, integrating seamlessly into that workflow.
-
Contact our team or request a quote at admerahealth.com/request-quote. Download the Sample Submission Guidelines to prepare your samples ahead of time. Admera Health works with organizations in a research use only capacity.
Analysis, deliverables & turnaround
Get the Most out of Your Study
Maximize your project’s potential with advanced analysis solutions. Our team of expert bioinformaticians curate pipelines tailored to your project’s experimental design.
HOW RESEARCHERS ARE USING SPATIAL TRANSCRIPTOMICS DATA
Applications of Spatial Transcriptome Profiling
Embryonic Development
Spatially resolved transcriptomics reveals dynamic gene activity during embryogenesis and organogenesis.
Neuroscience
Map gene expression to understand neurodegenerative diseases, neurological disorders, brain development, and aging at cellular resolution.
Immunology
Spatially resolve immune cell infiltration, phenotypes, and cell-cell interactions within tissues to understand immune responses
Oncology
Map tumor heterogeneity, tumor microenvironment (TME) composition, and cell-cell interactions to identify drug targets, predict treatment response/resistance, and understand cancer progression in situ
Not sure where to start?
Talk to one of our scientists.
A free 30-minute project consultation with a PhD-level scientist. We'll help you pick the right platform, flag sample prep considerations, and estimate costs before you commit to anything.
Sending samples?
See our sample submission guideline for sample preparation, packing, and shipping instructions.