Solid Tumor Profiling from Tissue
for Targeted Therapy Selection

OncoGxSelect™ is a NGS panel that
aligns with well-established guidelines

OncoGxOne™ provides clinicians with
a comprehensive option for their tumor profiling needs

Solid Tumor Profiling from Tissue
for Targeted Therapy Selection

OncoGxSelect™ is a NGS panel that
aligns with well-established guidelines

OncoGxOne™ provides clinicians
with a comprehensive option for
their tumor profiling needs

oncogxselect Solid Tumor Profiling

OncoGxSelect™ analyzes a patient’s tumor for genetic mutations frequently found in select cancers. This test utilizes Next Generation Sequencing (NGS) technology to detect alterations in 12 known oncogenes and is aligned with well-established molecular testing guidelines. Actionable results help guide therapeutic decisions related to targeted cancer therapy. Additionally, OncoGxSelect™ detects all types of mutations (SNV, gene fusion, Indel, CNV) with a high degree of accuracy.

View OncoGxOne™ Comprehensive Panel

Target Onco Genes

ALKBRAFEGFRERBB2KITKRAS
MAP2K1METNRASPIK3CARETROS1

Relevant Solid Tumor Types

GeneVariantTypeResponsiveResistant
ALKEML4-ALKFusionCrizotinib, Ceritinib, AlectinibGefitinib, Erlotinib, Afatinib
KIF5B-ALK
TFG-ALK
T1151_L1152insTIndelCrizotinib
L1152RSNV
C1156Y
F1174L
L1196MBrigatinib
G1202R
S1206Y
G1269A
BRAFV600ESNVVemurafenib, Dabrafenib, Dabrafenib+Trametinib
ERBB2A775_G776insYVMAIndelTrastuzumab, Afatinib
G776_777insVC
Exon20_ins
G776LSNVTrastuzumab
EGFRG719ASNVGefitinib, Erlotinib
G719C
G719S
D761YGefitinib, Erlotinib
K745_A750delIndelGefitinib, Erlotinib, Afatinib
E746_A750del
E746_A750delELREA
E746_S752delinsA
L747_S752del
Exon19_del
A763_Y764insFQEA
D770_N771insSVDGefitinib, Erlotinib
Exon20_ins
T790MSNVOsimertinib
C797SOsimertinib
L858RGefitinib, Erlotinib, Afatinib
L861QGefitinib, Erlotinib
KRASG12ASNVGefitinib, Erlotinib
G12C
G12D
G12R
G12S
G12V
G13A
G13C
G13D
G13R
G13S
G13V
Q61H
Q61K
Q61L
Q61R
METAmplificationCNVCrizotinib
Exon14_skippingFusion
RETNCOA4-RETFusionCabozantinib
CCDC6-RET
KIF5B-RET
ROS1CD74-ROS1FusionCrizotinib
GOPC-ROS1
SLC34A2-ROS1
EZR-ROS1
SDC4-ROS1
TPM3-ROS1
LRIG3-ROS1
GeneVariantTypeResponsiveResistant
BRAFV600ESNVDabrafenib+Trametinib, Vemurafenib+Cobimetinib
V600KDabrafenib+Trametinib, Vemurafenib+Cobimetinib, Vemurafenib, Dabrafenib
KITAmplificationCNVImatinib
W557RSNV
V559A
V560D
L576P
K642E
MAP2K1C121SSNVTrametinib
GeneVariantTypeResponsiveResistant
ALKSTRN-ALKFusionCrizotinib, Ceritinib
EML4-ALK
BRAFV600ESNVVemurafenib, Dabrafenib
EGFRAmplificationCNVVandetanib
METAmplificationCNVCabozantinib
RETNCOA4-RETFusionVandetanib, Cabozantinib
CCDC6-RET
C634WSNVVandetanib
C634R
C634Y
M918T
GeneVariantTypeResponsiveResistant
N/AWTCetuximab, Panitumumab
BRAFV600ESNVCetuximab, Panitumumab
KRASG12ASNVCetuximab, Panitumumab
G12C
G12D
G12R
G12S
G12V
G13A
G13C
G13D
G13R
G13S
G13V
Q61H
Q61K
Q61L
Q61R
K117N
A146P
A146T
A146V
NRASG12ASNVCetuximab, Panitumumab
G12C
G12D
G12R
G12S
G12V
G13A
G13C
G13D
G13R
G13S
G13V
Q61H
Q61K
Q61L
Q61R
GeneVariantTypeResponsiveResistant
ERBB2AmplificationCNVTrastuzumab,  Trastuzumab+Chemotherapy
EGFROverexpressionNimotuzumab
KITWTRegorafenibImatinib
L576PSNVImatinib
W557R
V559A
K642E
V560delIndel
PDGFRAD842VSNVDasatinibImatinib
GeneVariantTypeResponsiveResistant
ERBB2AmplificationCNVTrastuzumab,  Trastuzumab+Chemotherapy
PIK3CAH1047RSNVTemsirolimus, Everolimus
oncogxone-sm Solid Tumor Profiling

OncoGxOne™ is a comprehensive Next Generation Sequencing (NGS) based test that profiles tumors for targeted therapy selection and chemotherapeutic tolerance.

  • 64 gene panel: 56 cancer related genes and 8 genes related to pharmacogenomics.
  • Comprehensive coverage of clinically actionable alterations found in multiple cancer types, covering all exons, 5’ and 3’ UTRs, and select introns known to harbor breakpoints.
  • Detects SNV, indel, CNV and gene fusion
GeneTherapeutic Area
ABL1Chronic Myeloid Leukemia
AKT1Breast Cancer
Colorectal Cancer
Non-Small Cell Lung Cancer
ALKAnaplastic Large Cell Lymphoma
Inflammatory Myofibroblastic Tumor
Neuroblastoma
Non-Small Cell Lung Cancer
Rhabdomyosarcoma
ATMDiffuse Large B-Cell Lymphoma
Mantle Cell Lymphoma
Chronic Lymphocytic Leukemia
AURKAColorectal Cancer
BCL2Lymphoma
BCL6Lymphoma
BCRChronic Myeloid Leukemia
BRAFColorectal Cancer
Gastrointestinal Stromal Tumor
Glioma
Melanoma
Non-Small Cell Lung Cancer
Ovarian Cancer
Thyroid Cancer
BRCA1Breast Cancer
Ovarian Cancer
BRCA2Breast Cancer
 Ovarian Cancer
CCND1Breast Cancer
GeneTherapeutic Area
CCNE1Ovarian Cancer
CDK4Breast Cancer
Liposarcoma
CEBPAAcute Myeloid Leukemia
CRLF2Acute Lymphoblastic Leukemia
CTNNB1Melanoma
DDR2Non-Small Cell Lung Cancer
DNMT3AAcute Myeloid Leukemia
Myelodysplastic Syndromes
EGFRColorectal Cancer
Glioblastoma
Head and Neck Squamous Cell Carcinoma
Non-Small Cell Lung Cancer
ERBB2Breast Cancer
Gastric Cancer
Non-Small Cell Lung Cancer
ESR1Breast Cancer
ETV6Myelodysplastic Syndromes
Prostate Cancer
FGFR1Breast Cancer
Non-Small Cell Lung Cancer
FGFR2Breast Cancer
FGFR3Bladder Cancer
Glioblastoma
FLT3Acute Lymphoblastic Leukemia
Acute Myeloid Leukemia
GNA11Melanoma
GNAQMelanoma
GeneTherapeutic Area
HRASThyroid Cancer
IDH1Acute Myeloid Leukemia
Glioma
IDH2Acute Myeloid Leukemia
Glioma
JAK1Acute Lymphoblastic Leukemia
Myeloproliferative Neoplasms
JAK2Acute Lymphoblastic Leukemia
Myeloproliferative Neoplasms
KITAcute Myeloid Leukemia
Gastrointestinal Stromal Tumor
Melanoma
Non-Small Cell Lung Cancer
Thymic Carcinoma
KMT2AAcute Myeloid Leukemia
KRASColorectal Cancer
Non-Small Cell Lung Cancer
Ovarian Cancer
Thyroid Cancer
MAP2K1Melanoma
Non-Small Cell Lung Cancer
METNon-Small Cell Lung Cancer
MPLHaematopoietic Neoplasms
MYCSmall Cell Lung Cancer
NF1Melanoma
Myelodysplastic Syndromes
NPM1Anaplastic Large Cell Lymphoma
Acute Myeloid Leukemia
GeneTherapeutic Area
NRASColorectal Cancer
Melanoma
Non-Small Cell Lung Cancer
Thyroid Cancer
PDGFRAGastrointestinal Stromal Tumor
PDGFRBMyeloid Neoplasms
PIK3CABreast Cancer
Colorectal Cancer
Non-Small Cell Lung Cancer
Ovarian Cancer
Squamous Cell Cervical Cancer
PTCH1Gastric Cancer
Medulloblastoma
PTENBreast Cancer
Colorectal Cancer
Non-Small Cell Lung Cancer
Ovarian Cancer
RARAAcute Myeloid Leukemia
RETNon-Small Cell Lung Cancer
Thyroid Cancer
ROS1Non-Small Cell Lung Cancer
RUNX1Acute Myeloid Leukemia
Myelodysplastic Syndromes
SMOBasal Cell Carcinoma
Medulloblastoma
TP53Cancer
Myelodysplastic Syndromes
TSC1Bladder Cancer

Pharmacogenomics Related Genes

CYP2C8CYP2D6DPYDMTHFRTPMTTYMSUGT1A1XRCC1
Ado-trastuzumab emtansine (Kadcyla)Goserelin (Zoladex)Regorafenib (Stivarga)
Afatinib (Gilotrif)Imatinib (Gleevec)Ruxolitinib (Jakafi)
Alectinib (Alecensa)Ipilimumab (Yervoy)Sirolimus (Rapamune)
Anastrozole (Arimidex)Lapatinib (Tykerb)Sorafenib (Nexavar)
Bosutinib (Bosulif)Lenvatinib (Lenvima)Sunitinib (Sutent)
Cabozantinib (Cometriq)Letrozole (Femara)Tamoxifen (Soltamox; Nolvadex)
Ceritinib (Zykadia)Leuprolide (Lupron; Eligard)Temsirolimus (Torisel)
Cetuximab (Erbitux)Nilotinib (Tasigna)Tofacitinib (Xeljanz)
Cobimetinib (Cotellic)Nintedanib (OFEV)Toremifene (Fareston)
Crizotinib (Xalkori)Nivolumab (Opdivo)Trametinib (Mekinist)
Dabrafenib (Tafinlar)Olaparib (Lynparza)Trastuzumab (Herceptin)
Dasatinib (Sprycel)Osimertinib (Tagrisso)Tretinoin; ATRA (Vesanoid)
Erlotinib (Tarceva)Palbociclib (Ibrance)Vandetanib (Caprelsa)
Everolimus (Zortress; Affinitor)Panitumumab (Vectibix)Vemurafenib (Zelboraf)
Exemestane (Aromasin)Pazopanib (Votrient)Vismodegib (Erivedge)
Fulvestrant (Faslodex)Pertuzumab (Perjeta)
Gefitinib (Iressa)Ponatinib (Iclusig)
Arsenic trioxide (Trisenox)Docetaxel (Taxotere)Paclitaxel (Onxol; Abraxane)
Capecitabine (Xeloda)Fluorouracil (5-FU)Mercaptopurine (Purinethol)
Carboplatin (Paraplatin)Irinotecan (Camptosar)Thioguanine (Tabloid)
Cisplatin (Platinol)Leucovorin (Wellcovorin)
Cyclophosphamide (Endoxan)Oxaliplatin (Eloxatin)
Crenolanib (CP-868-596)Ganetespib (STA-9090)Retaspimycin (IPI-504)
Dacomitinib (PF-00299804)Neratinib (HKI-272)Rociletinib (CO-1686)
Dinaciclib (SCH-727965)Quizartinib (AC220)Selumetinib (AZD6244)
Dovitinib (TKI258)Refametinib (BAY86-9766)Tanespimycin (17-AAG)

Types of Alterations Detected

SNVs1 Solid Tumor Profiling

SNVs

Fusions Solid Tumor Profiling

Fusions

CNVS2 Solid Tumor Profiling

CNVs

Indels Solid Tumor Profiling

Indels

OncoGxSelect™ Report

Sample Report
OncoGxOne__Plus_Sample_report_thumb Solid Tumor Profiling

OncoGxSelect™ Information Sheet

Information Sheet
OncoGxSelect_Info_sheet_thumb-1 Solid Tumor Profiling