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Genetics for Smarter Medication Management

PGxOne™ Plus is a 60+ gene pharmacogenomics (PGx) test that provides insight into how patients may respond to certain medications based on DNA variants that affect pharmacokinetics and pharmacodynamics. Using Next-Generation molecular biology technologies, the test provides results aligning with FDA sources and guidelines from professional organizations.1,2

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PGxOnePlus_RxVision_logo_WHITE_FINAL PGxOne™ Plus


Genetics for Smarter Medication Management

PGxOne™ Plus is a 60+ gene pharmacogenomics (PGx) test that provides insight into how patients may respond to certain medications based on DNA variants that affect pharmacokinetics and pharmacodynamics. Using Next-Generation molecular biology technologies, the test provides results aligning with FDA sources and guidelines from professional organizations.1,2

be8fda7f-53fd-4231-ad5f-1500bf86dcce PGxOne™ Plus
f2726b9d-243a-4bfa-b849-4a44598967d9 PGxOne™ Plus
2797943f-219f-424e-8f07-bd570f67c057 PGxOne™ Plus

PGxOne™ Plus provides an additional tool for making informed drug management decisions with the goal of reducing adverse drug reactions and trial-and-error dosing and drug selection.

Reasons to order pharmacogenomics testing:

            • When the FDA requires/recommends pharmacogenomics (PGx) testing for a medication
            • When the patient has had a severe adverse drug reaction(s) or complications due to medications
            • There is a family history of a serious adverse drug reaction or known pharmacogenomic variant
            • Identifying patients who require a higher or lower-than–standard dose of a medication
            • When patients have experienced multiple treatment failures
            • The recommended drug dosage has not relieved symptoms or the patient has sensitivity to a medication
            • When a patient is experiencing unexpected or exaggerated response(s) to a medication(s)
            • To improve a patient’s medication compliance/adherence
            • For patients who are on multiple medications
            • PGx testing can be taken preemptively so the results can be readily available when needed
              *References Available

Pharmacogenomics helps to reduce unfavorable outcomes in patients infected with COVID-19 with underlying high-risk medical conditions. 

4a180cf0-a85d-424b-b936-4db97aec47ce PGxOne™ Plus

Gene-Drug Interactions in the form of Clear, Color-Coded Medically Actionable Results

Consider-Alt-Icon PGxOne™ Plus

Consider Alternatives: refers to gene-drug pairs in which the interaction between a drug and one or several genes may result in a clinically severe and potentially deadly adverse drug reaction(s) and lack of efficacy. Most medications included in this gene-drug pair category still can be used. However, extreme caution and clinical judgment should be exercised. Providers should share the corresponding gene-drug interaction with their patients and follow FDA recommendations.

Caution-Icon PGxOne™ Plus

Use with Caution: refers to gene-drug pairs in which the interaction between a drug and one or several genes may result in a mild adverse drug reaction(s) and lack of efficacy. Most medications included in this gene-drug pair category still can be used. However, caution and clinical judgment should be exercised. Providers should share the corresponding gene-drug interaction with their patients and follow FDA recommendations.

Drug-Management-Icon PGxOne™ Plus

Drug Management: refers to gene-drug pairs in which a negative drug response (adverse drug reaction(s) and lack of efficacy) might be preventable by adjusting the medication to the patient’s individual needs based on pharmacogenomic results and any other non-genetic factors of your knowledge. Providers should exercise caution and clinical judgment, share the corresponding gene-drug interaction their patients, and follow FDA recommendations.

Norml-Response-Icon PGxOne™ Plus

Normal Response Expected: refers to gene-drug pairs in which the corresponding drug response (adverse drug reaction(s) risk and efficacy) shall correlate with the FDA label description and is like that of the general population. Keep in mind that all drugs come with associated risks and should be taken into consideration when prescribing any medication. Providers should exercise caution and clinical judgment, share the corresponding gene-drug interaction their patients, and follow FDA recommendations.

PGxOne™ Plus provides an additional tool for making informed drug management decisions with the goal of reducing adverse drug reactions and trial-and-error dosing and drug selection.

Reasons to order pharmacogenomics testing:

      • When the FDA requires/recommends pharmacogenomics (PGx) testing for a medication
      • When the patient has had a severe adverse drug reaction(s) or complications due to medications
      • There is a family history of a serious adverse drug reaction or known pharmacogenomic variant
      • Identifying patients who require a higher or lower-than–standard dose of a medication
      • When patients have experienced multiple treatment failures
      • The recommended drug dosage has not relieved symptoms or the patient has sensitivity to a medication
      • When a patient is experiencing unexpected or exaggerated response(s) to a medication(s)
      • To improve a patient’s medication compliance/adherence
      • For patients who are on multiple medications
      • PGx testing can be taken preemptively so the results can be readily available when needed
        *References Available

Pharmacogenomics helps to reduce unfavorable outcomes in patients infected with COVID-19 with underlying high-risk medical conditions. 

4a180cf0-a85d-424b-b936-4db97aec47ce PGxOne™ Plus

Gene-Drug Interactions in the form of Clear, Color-Coded Medically Actionable Results

Consider-Alt-Icon PGxOne™ Plus

Consider Alternatives: refers to gene-drug pairs in which the interaction between a drug and one or several genes may result in a clinically severe and potentially deadly adverse drug reaction(s) and lack of efficacy. Most medications included in this gene-drug pair category still can be used. However, extreme caution and clinical judgment should be exercised. Providers should share the corresponding gene-drug interaction with their patients and follow FDA recommendations.

Caution-Icon PGxOne™ Plus

Use with Caution: refers to gene-drug pairs in which the interaction between a drug and one or several genes may result in a mild adverse drug reaction(s) and lack of efficacy. Most medications included in this gene-drug pair category still can be used. However, caution and clinical judgment should be exercised. Providers should share the corresponding gene-drug interaction with their patients and follow FDA recommendations.

Drug-Management-Icon PGxOne™ Plus

Drug Management: refers to gene-drug pairs in which a negative drug response (adverse drug reaction(s) and lack of efficacy) might be preventable by adjusting the medication to the patient’s individual needs based on pharmacogenomic results and any other non-genetic factors of your knowledge. Providers should exercise caution and clinical judgment, share the corresponding gene-drug interaction their patients, and follow FDA recommendations.

Norml-Response-Icon PGxOne™ Plus

Normal Response Expected: refers to gene-drug pairs in which the corresponding drug response (adverse drug reaction(s) risk and efficacy) shall correlate with the FDA label description and is like that of the general population. Keep in mind that all drugs come with associated risks and should be taken into consideration when prescribing any medication. Providers should exercise caution and clinical judgment, share the corresponding gene-drug interaction their patients, and follow FDA recommendations.

Actionable Reports

Easy to read reports with gene-drug interactions aligning with the FDA’s latest recommendations

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Search by Drug, Therapeutic Area, or Drug Class

PGxOne™ Plus provides gene-drug interactions for an extensive range of medications used widely in psychiatry, cardiology, pain management, oncology, and multiple other clinical specialties.

Medication Table
Search by DrugSearch by Therapeutic AreaSearch by GeneSearch by Drug ClassSearch All
Therapeutic AreaDrug ClassDrug NameGene
ANESTHESIOLOGYDepolarizing Neuromuscular Blocker AgentsSuccinylcholine (Anectine®; Quelicin®)BCHE
ANESTHESIOLOGYMusculoskeletal AgentsMivacurium (Mivacron®)BCHE
CARDIOLOGYAlpha and Beta Adrenergic BlockersCarvedilol (Coreg®)CYP2D6
CARDIOLOGYAntiarrhythmic AgentsProcainamideNAT2
CARDIOLOGYAntiarrhythmic Agents Propafenone (Rythmol SR®)CYP2D6
CARDIOLOGYAnticoagulants Warfarin (Coumadin®; Jantoven®)
CYP2C9
CARDIOLOGYAnticoagulants Warfarin (Coumadin®; Jantoven®)
VKORC1
CARDIOLOGYAnticoagulants Warfarin (Coumadin®; Jantoven®)
CYP4F2
CARDIOLOGYAntilipemic Agents (statins)
Rosuvastatin (Crestor®; Ezallor Sprinkle®)
SLCO1B1
CARDIOLOGYAntilipemic Agents (statins)
Simvastatin (Zocor®)
SLCO1B1
CARDIOLOGYAntiplatelets Clopidogrel (Plavix®)
CYP2C19
CARDIOLOGYBeta Blockers
Metoprolol (Lopressor®; Toprol XL®)
CYP2D6
CARDIOLOGYBeta Blockers
Nebivolol (Bystolic®)
CYP2D6
CARDIOLOGYBeta Blockers
Propranolol (Inderal®; Inderal LA®;
InnoPran XL®; Propranolol HCl Intensol®;
Inderal XL®; Hemangeol®)
CYP2D6
CARDIOLOGYPeripheral Vasodilators
Hydralazine (Apresoline®)
NAT2
DENTISTRYCholinergic Agonists
Cevimeline (Evoxac®)
CYP2D6
DERMATOLOGYAntineoplastic Agents
Fluorouracil (Adrucil®; Carac®)
DPYD
DERMATOLOGYDermatology Agents
Doxepin (Silenor®; Zonalon®;
Sinequan®; Prudoxin®)
CYP2D6
DERMATOLOGYDermatology Agents
Doxepin (Silenor®; Zonalon®;
Sinequan®; Prudoxin®)
CYP2C19
DERMATOLOGYImmunosuppressant Agents
Tacrolimus (Astagraf XL®; Prograf®;
Protopic®; Envarsus XR®)
CYP3A5
ENDOCRINOLOGYEndocrine Metabolic AgentsEliglustat (Cerdelga®)CYP2D6
GASTROENTEROLOGY5-Aminosalicylic Acid Derivatives
Sulfasalazine (Azulfidine®)
NAT2
GASTROENTEROLOGYAcid Reducing Agents
Dexlansoprazole (Dexilant®)
CYP2C19
GASTROENTEROLOGYAcid Reducing Agents
Esomeprazole (Nexium®)
CYP2C19
GASTROENTEROLOGYAcid Reducing Agents
Omeprazole (Prilosec®)
CYP2C19
GASTROENTEROLOGYAcid Reducing Agents
Pantoprazole (Protonix®)
CYP2C19
GASTROENTEROLOGYAcid Reducing Agents
Rabeprazole (AcipHex®)
CYP2C19
GASTROENTEROLOGYAntiemeticsMeclizine (Antivert®; Bonine®; Dramamine
Less Drowsy®; Motion-Time®; Travel
Sickness®; Travel-Easy®)
CYP2D6
GASTROENTEROLOGYAntiemetics Metoclopramide (Reglan®)CYP2D6
GYNECOLOGYCentral Nervous System Agents
Flibanserin (Addyi®)
CYP2C19
GYNECOLOGYEndocrine Metabolic Agents
Elagolix (Orilissa®)
SLCO1B1
HEMATOLOGYColony Stimulating Factors
Avatrombopag (Doptelet®)
CYP2C9
IMMUNOLOGYImmunomodulatory Agents
Siponimod (Mayzent®)
CYP2C9
IMMUNOLOGYImmunosuppressant Agents
Azathioprine (Azasan®; Imuran®)
TPMT
IMMUNOLOGYImmunosuppressant Agents
Azathioprine (Azasan®; Imuran®)
NUDT15
INFECTIOUS DISEASES
Antifungal Agents
Voriconazole (Vfend®)
CYP2C19
INFECTIOUS DISEASES
Antitubercular Agents
Isoniazid (Nydrazid®)
NAT2
INFECTIOUS DISEASES
Antiretrovirals Abacavir (Ziagen®)
HLA-B
INFECTIOUS DISEASES
Antiretrovirals Dolutegravir (Tivicay®)
UGT1A1
INFECTIOUS DISEASES
Antiretrovirals Efavirenz (Sustiva®)
CYP2B6
INFECTIOUS DISEASES
Antiretrovirals Raltegravir (Isentress®)
UGT1A1
INFECTIOUS DISEASES
Sulfonamide Antibiotics
Sulfamethoxazole and Trimethoprim
(Bactrim®; Septra®; Sulfatrim®)
NAT2
NEUROLOGYAnticonvulsants Brivaracetam (Briviact®)
CYP2C19
NEUROLOGYAnticonvulsants Carbamazepine (Carbatrol®; Epitol®;
Equetro®; Tegretol®; Tegretol-XR®)
HLA-A
NEUROLOGYAnticonvulsants Carbamazepine (Carbatrol®; Epitol®;
Equetro®; Tegretol®; Tegretol-XR®)
HLA-B
NEUROLOGYAnticonvulsants Clobazam (Onfi®; Sympazan®)
CYP2C19
NEUROLOGYAnticonvulsants Oxcarbazepine (Oxtellar®; Trileptal®)
HLA-B
NEUROLOGYAnticholinergic Agents
Donepezil (Aricept®)
CYP2D6
NEUROLOGYAnticholinergic Agents
Galantamine (Razadyne®; Razadyne ER®)
CYP2D6
NEUROLOGYCentral Monoamine-Depleting Agents
Deutetrabenazine (Austedo®)
CYP2D6
NEUROLOGYCentral Nervous System Agents
Amifampridine (Ruzurgi®)
NAT2
NEUROLOGYCentral Nervous System Agents
Amifampridine Phosphate (Firdapse®)
NAT2
NEUROLOGYCentral Nervous System Agents
Atomoxetine (Strattera®)
CYP2D6
NEUROLOGYCentral Nervous System Stimulants
Amphetamine (Dyanavel XR®; Adzenys
XR-ODT®; Adzenys ER®)
CYP2D6
NEUROLOGYDepolarizing Neuromuscular Agents
Succinylcholine (Anectine®; Quelicin®)
BCHE
NEUROLOGYMonoamine Depletors
Tetrabenazine (Xenazine®)
CYP2D6
NEUROLOGYMonoamine Depletors
Valbenazine (Ingrezza®)
CYP2D6
ONCOLOGYAntiemetics Dronabinol (Syndros®)
CYP2C9
ONCOLOGYAntiemetics Metoclopramide (Reglan®)
CYP2D6
ONCOLOGYAntiestrogens Tamoxifen (Soltamox®)
CYP2D6
ONCOLOGYAntineoplastic Agents
Belinostat (Beleodaq®)
UGT1A1
ONCOLOGYAntineoplastic Agents
Capecitabine (Xeloda®)
DPYD
ONCOLOGYAntineoplastic Agents
Erdafitinib (Balversa®)
CYP2C9
ONCOLOGYAntineoplastic Agents
Fluorouracil (Adrucil®; Carac®)
DPYD
ONCOLOGYAntineoplastic Agents
Gefitinib (Iressa®)
CYP2D6
ONCOLOGYAntineoplastic Agents
Irinotecan (Camptosar®; Ovivyde®)
UGT1A1
ONCOLOGYAntineoplastic Agents
Mercaptopurine (Purinethol®; Purixan®)
TPMT
ONCOLOGYAntineoplastic Agents
Mercaptopurine (Purinethol®; Purixan®)
NUDT15
ONCOLOGYAntineoplastic Agents
Nilotinib (Tasigna®)
UGT1A1
ONCOLOGYAntineoplastic Agents
Pazopanib (Votrient®)
UGT1A1
ONCOLOGYAntineoplastic Agents
Pazopanib (Votrient®)
HLA-A
ONCOLOGYAntineoplastic Agents
Thioguanine (Tabloid®)
TPMT
ONCOLOGYAntineoplastic Agents
Thioguanine (Tabloid®)
NUDT15
ONCOLOGYImmunosuppressant Agents
Tacrolimus (Astagraf XL®; Prograf®;
Protopic®; Envarsus XR®)
CYP3A5
PAIN MANAGEMENT
Muscle Relaxants
Carisoprodol (Soma®; Vanadom®)
CYP2C19
PAIN MANAGEMENT
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Celecoxib (Celebrex®)
CYP2C9
PAIN MANAGEMENT
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Flurbiprofen (Ansaid®)
CYP2C9
PAIN MANAGEMENT
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Piroxicam (Feldene®)
CYP2C9
PAIN MANAGEMENT
OpioidsCodeineCYP2D6
PAIN MANAGEMENT
Opioids Tramadol (Ultram®; ConZip®)
CYP2D6
PAIN MANAGEMENT
Opioid Dependencies
Lofexidine (Lucemyra®)
CYP2D6
PSYCHIATRYAntidepressants Citalopram (Celexa®)
CYP2C19
PSYCHIATRYAntidepressants Doxepin (Silenor®; Zonalon®;
Sinequan®; Prudoxin®)
CYP2D6
PSYCHIATRYAntidepressants Doxepin (Silenor®; Zonalon®;
Sinequan®; Prudoxin®)
CYP2C19
PSYCHIATRYAntidepressants Escitalopram (Lexapro®)
CYP2C19
PSYCHIATRYAntidepressants Fluvoxamine (Luvox®; Luvox CR®)
CYP2D6
PSYCHIATRYAntidepressants Paroxetine (Paxil®; Pexeva®; Brisdelle®)
CYP2D6
PSYCHIATRYAntidepressants Venlafaxine (Effexor®)
CYP2D6
PSYCHIATRYAntidepressants Vortioxetine (Trintellix®)
CYP2D6
PSYCHIATRYAntipsychotics Aripiprazole (Abilify®)
CYP2D6
PSYCHIATRYAntipsychoticsAripiprazole Lauroxil (Aristada®;
Aristada Initio®)
CYP2D6
PSYCHIATRYAntipsychotics Brexpiprazole (Rexulti®)
CYP2D6
PSYCHIATRYAntipsychotics Clozapine (Clozaril®; Versacloz®)
CYP2D6
PSYCHIATRYAntipsychotics Iloperidone (Fanapt®)
CYP2D6
PSYCHIATRYAntipsychotics Perphenazine (Trilafon®)
CYP2D6
PSYCHIATRYAntipsychotics Pimozide (Orap®)
CYP2D6
PSYCHIATRYAntipsychotics Risperidone (Risperdal®)
CYP2D6
PSYCHIATRYAntipsychotics Thioridazine (Mellaril®)
CYP2D6
PSYCHIATRYBenzodiazepineDiazepam (Valium®; Diastat AcuDial®;
Diazepam Intensol®; Diastat Pediatric®)
CYP2C19
PSYCHIATRYSleep Aids
Doxepin (Silenor®; Zonalon®; Sinequan®;
Prudoxin®)
CYP2D6
PSYCHIATRYSleep Aids
Doxepin (Silenor®; Zonalon®; Sinequan®;
Prudoxin®)
CYP2C19
PSYCHIATRYTricyclic Antidepressants
Amitriptyline (Elavil®; Vanatrip®)
CYP2D6
PSYCHIATRYTricyclic Antidepressants
Amoxapine (Asendin®)
CYP2D6
PSYCHIATRYTricyclic Antidepressants
Clomipramine (Anafranil®)
CYP2D6
PSYCHIATRYTricyclic Antidepressants
Desipramine (Norpramin®)
CYP2D6
PSYCHIATRYTricyclic Antidepressants
Imipramine (Tofranil®)
CYP2D6
PSYCHIATRYTricyclic Antidepressants
Nortriptyline (Pamelor®)
CYP2D6
PSYCHIATRYTricyclic Antidepressants
Protriptyline (Vivactil®)
CYP2D6
PSYCHIATRYTricyclic Antidepressants
Trimipramine (Surmontil®)
CYP2D6
RHEUMATOLOGY5-Aminosalicylic Acid Derivatives
Sulfasalazine (Azulfidine®)
NAT2
RHEUMATOLOGYAntigout Agents
Allopurinol (Zyloprim®)
HLA-B
RHEUMATOLOGYAntirheumatics Azathioprine (Azasan®; Imuran®)
TPMT
RHEUMATOLOGYAntirheumatics Azathioprine (Azasan®; Imuran®)
NUDT15
RHEUMATOLOGYNon-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Celecoxib (Celebrex®)
CYP2C9
RHEUMATOLOGYNon-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Flurbiprofen (Ansaid®)
CYP2C9
RHEUMATOLOGYNon-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Piroxicam (Feldene®)
CYP2C9
UROLOGYAlpha 1 Blockers
Tamsulosin (Flomax®)
CYP2D6
UROLOGYAnticholinergic Agents
Darifenacin (Enablex®)
CYP2D6
UROLOGYAnticholinergic Agents
Fesoterodine (Toviaz®)
CYP2D6
UROLOGYAnticholinergic Agents
Tolterodine (Detrol®)
CYP2D6
UROLOGYGenitourinary Agents
Mirabegron (Myrbetriq®)
CYP2D6

No Results Found

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Admera Health’s dynamic online reporting tool pairs the PGxOne™ Pus test to provide a complete PGx assessment.

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Sample Collection

This video, produced by DNA Genotek, walks you through the process for proper sample collection. This will reduce the need for resampling and yield accurate test results.

Sample Collection

This video, produced by DNA Genotek, walks you through the process for proper sample collection. This will reduce the need for resampling and yield accurate test results.