Improve outcomes by
personalizing treatment
decisions based on genetics

PGxOne™ Plus is a genetic test
for predicting therapeutic response

Over 50 genes | Over 200 variants | Over 300 drugs
Covering 20 therapeutic areas | Over 310 medical conditions

Sample Report
Sample Report
Information Sheet
Information Sheet
PGxOne_Plus_logo_final_plus_updated1-e1524157998488 PGxOne™ Plus

A single test to improve treatment outcomes,
reduce harmful interactions, maximize quality of life, and lower costs

patients_sensitivity_icon-e1524157589529 PGxOne™ Plus
Ideal for patients
demonstrating sensitivity
or lack of symptom relief
reduce_risk_icon-e1524157620551 PGxOne™ Plus
Reduce risk for patients
with chronic conditions
and multiple prescription
Improve_Outcomes_Icon-e1524157652865 PGxOne™ Plus
Improve outcomes by
increasing patient
compliance
Lesson_Trial_and_Error_icon-e1524157669300 PGxOne™ Plus
Lessen the need for
trial-and-error
prescribing approaches
PGxOne_Plus_logo_final_plus_updated1-e1524157998488 PGxOne™ Plus

A single test to improve treatment outcomes, reduce harmful interactions, maximize quality of life, and lower costs

patients_sensitivity_icon-e1524157589529 PGxOne™ Plus
Ideal for patients demonstrating sensitivity or lack of symptom relief
reduce_risk_icon-e1524157620551 PGxOne™ Plus
Reduce risk for patients with chronic conditions and multiple prescription
Improve_Outcomes_Icon-e1524157652865 PGxOne™ Plus
Improve outcomes by increasing patient compliance
Lesson_Trial_and_Error_icon-e1524157669300 PGxOne™ Plus
Lessen the need for trial-and-error prescribing approaches
PGxOne_Plus_logo_final_plus_updated1-e1528986551516 PGxOne™ Plus

A single test to improve treatment outcomes, reduce harmful interactions, maximize quality of life, and lower costs

patients_sensitivity_icon-e1528986605209 PGxOne™ Plus
Ideal for patients
demonstrating sensitivity
or lack of symptom relief
reduce_risk_icon-e1528986643864 PGxOne™ Plus
Reduce risk for patients
with chronic conditions
and multiple prescription
Improve_Outcomes_Icon-e1528986669420 PGxOne™ Plus
Improve outcomes by
increasing patient
compliance
Lesson_Trial_and_Error_icon-e1528986788346 PGxOne™ Plus
Lessen the need for
trial-and-error
prescribing approaches

Reduce Adverse Drug Events

Genetic variants can lead to unexpected or exaggerated responses to medications,
including severe complications and adverse drug reactions.

Personalize_Treatment_graphic-e1524164105238 PGxOne™ Plus

Personalize Treatment

Develop treatment strategies and medication selection
based on a patient’s specific DNA variants.

Actionable Results

Indication specific section driven by diagnosis codes and current medications. Results are ready in 7-10 business days.

Actionable_Results_graphic-e1524164142394 PGxOne™ Plus
Expert_Analysis_graphic-e1524164210139 PGxOne™ Plus

Comprehensive Analysis

Expert curation has identified genes and drugs with
highest level of PGx evidence

Reduce Adverse Drug Events

Genetic variants can lead to unexpected or exaggerated responses to medications, including severe complications and adverse drug reactions.

Personalize_Treatment_graphic-e1530020645528 PGxOne™ Plus

Personalize Treatment

Develop treatment strategies and medication selection based on a patient’s specific DNA variants.

Actionable Results

Indication specific section driven by diagnosis codes and current medications. Results are ready in 7-10 business days.

Actionable_Results_graphic-300x300 PGxOne™ Plus
Expert_Analysis_graphic-e1524164210139 PGxOne™ Plus

Comprehensive Analysis

Expert curation has identified genes and drugs with highest level of PGx evidence

Reduce Adverse Drug Events

Genetic variants can lead to unexpected or exaggerated responses to medications, including severe complications and adverse drug reactions.

Personalize_Treatment_graphic-150x150 PGxOne™ Plus

Personalize Treatment

Develop treatment strategies and medication selection based on a patient’s specific DNA variants.

Actionable_Results_graphic-150x150 PGxOne™ Plus

Actionable Results

Indication specific section driven by diagnosis codes and current medications. Results are ready in 7-10 business days.

Expert_Analysis_graphic-150x150 PGxOne™ Plus

Expert Analysis

Expert curation has identified genes and drugs with
highest level of PGx evidence

Actionable Reports

PGxOne™ Plus testing provides patient-centric and easy-to-understand reports that prioritize a patient’s results driven by diagnosis and current medications.

View Sample Report
Search by Drug Class
PGxPlus_Report_Thumbnail PGxOne™ Plus

Clear, Color-Coded Results

Results provide the relevant information to make more informed treatment decisions

Recommendations Consider Both the Pharmacokinetics and Pharmacodynamics of
Gene-Drug Combinations

Pharmacokinetics_Chart@3x-100 PGxOne™ Plus

Search by Drug or Drug Class

Over 300 drugs covered

PGxOne™ Plus provides recommendations for an extensive range of
common drugs used widely in psychiatry, cardiology, pain management,
oncology, and multiple other clinical specialties

Search by DrugSearch by Therapeutic AreaSearch All
Therapeutic AreaDrug ClassDrug Name Gene
Infectious DiseasesAntiretroviral DrugsAbacavir (Ziagen®)HLA-B
Infectious DiseasesAntiretroviral DrugsAbacavir and Lamivudine (Epzicom®)HLA-B
Infectious DiseasesAntiretroviral DrugsAbacavir, Dolutegravir, and Lamivudine (Triumeq®)UGT1A1
Infectious DiseasesAntiretroviral DrugsAbacavir, Dolutegravir, and Lamivudine (Triumeq®)HLA-B
Infectious DiseasesAntiretroviral DrugsAbacavir, Lamivudine, and Zidovudine (Trizivir®)HLA-B
Pain ManagementOpioidsAlfentanil (Alfenta®)OPRM1
ImmunologyXanthine oxidase inhibitorsAllopurinol (Zyloprim®)HLA-B
PsychologyBenzodiazepinesAlprazolam (Xanax®)CYP3A4
CardiologyAntiarrhythmic DrugsAmiodarone (Cordarone®)CYP3A4
CardiologyAntiarrhythmic DrugsAmiodarone (Cordarone®)NOS1AP
PsychologyTricyclic AntidepressantsAmitriptyline (Elavil®)CYP2C19
PsychologyTricyclic AntidepressantsAmitriptyline (Elavil®)CYP2D6
CardiologyCalcium Channel BlockersAmlodipine (Norvasc®)CYP3A4
CardiologyCalcium Channel BlockersAmlodipine (Norvasc®)NOS1AP
CardiologyCCB/ACE inhibitorAmlodipine/Benazepril (Lotrel®)ACE
CardiologyCCB/ACE inhibitorAmlodipine/Benazepril (Lotrel®)CYP3A4
CardiologyCCB/ACE inhibitorAmlodipine/Benazepril (Lotrel®)NOS1AP
NeurologyCNS Stimulants (ADHD)Amphetamine (Adderall®)COMT
NeurologyCNS Stimulants (ADHD)Amphetamine (Adderall®)OPRM1
PsychologyAntipsychoticsAripiprazole (Abilify®)CYP2D6
PsychologyAntipsychoticsAripiprazole (Abilify®)CYP3A4
GastroenterologyOsmotic LaxativeAscorbic Acid(Moviprep)G6PD
Infectious DiseasesAntiretroviral DrugsAtazanavir (Reyataz®)UGT1A1
CardiologyBeta BlockerAtenolol (Tenormin®)ADRA2A
NeurologySNRI (ADHD)Atomoxetine (Strattera®)CYP2D6
CardiologyAntilipemic AgentAtorvastatin (Lipitor®)ABCB1
CardiologyAntilipemic AgentAtorvastatin (Lipitor®)APOE
CardiologyAntilipemic AgentAtorvastatin (Lipitor®)CYP3A4
CardiologyAntilipemic AgentAtorvastatin (Lipitor®)CYP3A5
CardiologyAntilipemic AgentAtorvastatin (Lipitor®)KIF6
CardiologyAntilipemic AgentAtorvastatin (Lipitor®)SLCO1B1
CardiologyAntilipemic AgentAtorvastatin/Ezetimibe (Liptruzet®)ABCB1
CardiologyAntilipemic AgentAtorvastatin/Ezetimibe (Liptruzet®)APOE
CardiologyAntilipemic AgentAtorvastatin/Ezetimibe (Liptruzet®)CYP3A4
CardiologyAntilipemic AgentAtorvastatin/Ezetimibe (Liptruzet®)CYP3A5
CardiologyAntilipemic AgentAtorvastatin/Ezetimibe (Liptruzet®)KIF6
CardiologyAntilipemic AgentAtorvastatin/Ezetimibe (Liptruzet®)SLOC1B1
ImmunologyImmunosuppressant AgentAzathioprine (Imuran®)TPMT
OncologyHistone Deacetylase (HDAC) InhibitorBelinostat (Beleodaq®)UGT1A1
CardiologyACE InhibitorsBenazepril (Lotensin®)ACE
CardiologyACE Inhibitors/DiureticBenazepril/HCTZ (Lotensin HCT®)ACE
CardiologyACE Inhibitors/DiureticBenazepril/HCTZ (Lotensin HCT®)AGTR1
Infectious DiseasesAntiretroviral DrugsBoceprevir (Victrelis®)IFNL3
Infectious DiseasesAntihepaciviral DrugsBoceprevir (Victrelis®)ITPA
PsychologyAntipsychotic AgentBrexpiprazole (Rexulti®)CYP2D6
NeurologyAnticonvulsant DrugsBrivaracetam (Briviact®)CYP2C19
CardiologyDiureticsBumetanide (Bumex®)ACE
Pain ManagementOpioidsBuprenorphine (Subutex®)CYP3A4
PsychologyOpioids AntagonistsBuprenorphine/Naloxone (Suboxone®)CYP3A4
PsychologyOpioids AntagonistsBuprenorphine/Naloxone (Suboxone®)OPRM1
PsychologyDopamine/Norepinephrine-Reuptake InhibitorBupropion (Wellbutrin®)CYP2B6
Smoking CessationSmoking Cessation AidBupropion (Zyban®)ANKK1
Weight ManagementAnorexiantBupropion/Naltrexone (Contrave®)ANKK1
Weight ManagementAnorexiantBupropion/Naltrexone (Contrave®)OPRM1
PsychologyAnti-anxiety AgentsBuspirone (Buspar®)HTR1A
OncologyTaxane DerivativeCabazitaxel (Jevtana®)CYP3A4
CardiologyAngiotensin II Receptor BlockersCandesartan (Atacand®)AGTR1
CardiologyARBs/DiureticCandesartan/HCTZ (Atacand HCT®)AGTR1
NeurologyOther StimulantsCannabinoidsFAAH
OncologyAntimetabolite (Pyrimidine Analog)Capecitabine (Xeloda®)DPYD
CardiologyACE InhibitorsCaptopril (Capoten®)ACE
CardiologyACE InhibitorsCaptopril (Capoten®)AGTR1
CardiologyACE Inhibitors/DiureticCaptopril/HCTZ (Capozide®)ACE
CardiologyACE Inhibitors/DiureticCaptopril/HCTZ (Capozide®)AGTR1
NeurologyAnticonvulsant DrugsCarbamazepine (Tegretol®)HLA-B
NeurologyAnticonvulsant DrugsCarbamazepine (Tegretol®)SCN2A
OncologyPlatinum AnalogCarboplatin (Paraplatin®)ERCC1
OncologyPlatinum AnalogCarboplatin (Paraplatin®)GSTP1
OncologyPlatinum AnalogCarboplatin (Paraplatin®)MTHFR
OncologyPlatinum AnalogCarboplatin (Paraplatin®)XRCC1
Pain ManagementSkeletal Muscle RelaxantCarisoprodol (Soma®)CYP2C19
CardiologyBeta BlockerCarvedilol (Coreg®)CYP2D6
Pain ManagementNonsteroidal Antiinflammatory Drugs (NSAIDs)Celecoxib (Celebrex®)CYP2C9
DentistryCholinergic AgonistsCevimeline (Evoxac®)CYP2D6
Infectious DiseasesAntimalarial DrugChloroquine (Aralen®)G6PD
PsychologyAntipsychotic AgentChlorpromazineCYP1A2
EndocrinologySulfonylureasChlorpropamide (Diabinese®)G6PD
CardiologyPhosphodiesterase InhibitorsCilostazol (Pletal®)CYP3A4
OncologyPlatinum AnalogCisplatin (Platinol®)ERCC1
OncologyPlatinum AnalogCisplatin (Platinol®)GSTP1
OncologyPlatinum AnalogCisplatin (Platinol®)NQO1
OncologyPlatinum AnalogCisplatin (Platinol®)XRCC1
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Citalopram (Celexa®)CYP2C19
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Citalopram (Celexa®)GRIK4
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Citalopram (Celexa®)HTR2A
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Citalopram (Celexa®)SLC6A4
NeurologyAnticonvulsant DrugsClobazam (Onfi®)CYP2C19
PsychologyTricyclic AntidepressantsClomipramine (Anafranil®)CYP2C19
PsychologyTricyclic AntidepressantsClomipramine (Anafranil®)CYP2D6
CardiologyAntiplateletsClopidogrel (Plavix®)CYP2C19
PsychologyAntipsychoticsClozapine (Clozaril®)ANKK1
PsychologyAntipsychoticsClozapine (Clozaril®)CYP2D6
PsychologyAntipsychoticsClozapine (Clozaril®)HTR2C
NeurologyOther StimulantsCocaineCNR1
Pain ManagementOpioidsCodeine (Codeine®)CYP2D6
Pain ManagementOpioidsCodeine (Codeine®)CYP3A4
Pain ManagementOpioidCodeine/Acetaminophen (Tylenol #3, #4®)CYP2D6
Pain ManagementSkeletal Muscle RelaxantCyclobenzaprine (Flexeril®)CYP1A2
OncologyAlkylating AgentCyclophosphamide (Cytoxan®)GSTP1
OncologyAlkylating AgentCyclophosphamide (Cytoxan®)MTHFR
OncologyAlkylating AgentCyclophosphamide (Cytoxan®)NQO1
ImmunologyImmunosuppressant AgentCyclosporine (Gengraf®)ABCB1
OncologyAntimetabolite (Pyrimidine Analog)Cytarabine (Depocyt®)CDA
OncologyBRAF Kinase InhibitorDabrafenib (Tafinlar®)G6PD
Infectious DiseasesAntihepaciviral DrugsDaclatasvir (Daklinza®)IFNL3
Infectious DiseasesMiscellaneous AntibioticDapsoneG6PD
Infectious DiseasesLipopeptideDaptomycin (Cubicin®)ABCB1
UrologyAnticholinergic AgentDarifenacin (Enablex®)CYP2D6
PsychologyTricyclic AntidepressantsDesipramine (Norpramin®)CYP2C19
PsychologyTricyclic AntidepressantsDesipramine (Norpramin®)CYP2D6
OncologyAntiemetic (Corticosteroid)Dexamethasone (Decadron®)ABCB1
GastroenterologyProton Pump Inhibitors (PPIs)Dexlansoprazole (Dexilant®)CYP2C19
AnesthesiologySedativeDexmedetomidine (Precedex®)ADRA2A
NeurologyCNS Stimulants (ADHD)Dexmethylphenidate (Focalin®)COMT
NeurologyCNS Stimulants (ADHD)Dextroamphetamine (Adderall®)COMT
NeurologyCNS Stimulants (ADHD)Dextroamphetamine (Adderall®)DRD1
NeurologyNMDA Receptor AntagonistDextromethorphan and Quinidine(Nuedexta®)CYP2D6
PsychologyBenzodiazepinesDiazepam (Valium®)CYP2C19
Pain ManagementNonsteroidal Antiinflammatory Drugs (NSAIDs)Diclofenac (Voltaren XR®)CYP2C9
CardiologyAntiarrhythmic DrugsDigoxin (Lanoxin®)ABCB1
CardiologyCalcium Channel BlockersDiltiazem (Cardizem®)CYP3A4
PsychologyAldehyde Dehydrogenase InhibitorDisulfiram (Antabuse®)ANKK1
OncologyTaxane DerivativeDocetaxel (Taxotere®)ERCC1
OncologyAntiemetic (Selective 5-HT3 Receptor Antagonist)Dolasetron (Anzemet®)NOS1AP
Infectious DiseasesAntiretroviral DrugsDolutegravir (Tivicay®)UGT1A1
NeurologyAcetylcholinesterase InhibitorDonepezil (Aricept®)CYP2D6
PsychologyTricyclic AntidepressantsDoxepin (Silenor®)CYP2C19
PsychologyTricyclic AntidepressantsDoxepin (Silenor®)CYP2D6
OncologyAnthracyclineDoxorubicin (Doxil®)ABCB1
OncologyAnthracyclineDoxorubicin (Doxil®)NQO1
OncologyAntiemetic; Appetite StimulantDronabinol (Marinol®)CYP2C9
CardiologyAntiarrhythmic DrugsDronedarone (Multaq®)CYP3A4
PsychologySerotonin and Norepinephrine Reuptake Inhibitors (SNRIs)Duloxetine (Cymbalta®)CYP1A2
UrologyAlpha 1 BlockerDutasteride/Tamsulosin (Jalyn®)CYP2D6
Infectious DiseasesAntiretroviral DrugsEfavirenz (Sustiva®)CYP2B6
Infectious DiseasesAntihepaciviral DrugsElbasvir and Grazoprevir (Zepatier®)IFNL3
NeurologyAntimigraine AgentEletriptan (Relpax®)CYP3A4
EndocrinologyEndocrine Enzyme InhibitorEliglustat (Cerdelga®)CYP2D6
HematologyColony Stimulating FactorEltrombopag (Promacta®)F5
CardiologyACE Inhibitors/DiureticEnalapril/HCTZ (Vaseretic®)AGTR1
NeurologyCOMT InhibitorsEntacapone (Comtan®)COMT
OncologyAnthracyclineEpirubicin (Ellence®)GSTP1
OncologyAnthracyclineEpirubicin (Ellence®)NQO1
OncologyEGFR Tyrosine Kinase InhibitorErlotinib (Tarceva®)UGT1A1
Infectious DiseasesMacrolidesErythromycin/sulfisoxazole (Pediazole®)G6PD
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Escitalopram (Lexapro®)CYP2C19
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Escitalopram (Lexapro®)SLC6A4
GastroenterologyProton Pump Inhibitors (PPIs)Esomeprazole (Nexium®)CYP2C19
Infectious DiseasesAntitubercular AgentEthambutol (Myambutol®)NAT2
ToxicologyAntidoteEthanolANKK1
ToxicologyAntidoteEthanolOPRM1
GynecologyOral ContraceptiveEthinyl Estradiol and Norelgestromin(Ortho Evra®)F5
GynecologyOral ContraceptiveEthinyl Estradiol/Drospirenone (Yaz®)CYP2C19
GastroenterologyHistamine H2 AntagonistFamotidine (Pepcid®)CYP2C19
GastroenterologyHistamine H2 Antagonist/NSAIDFamotidine/Ibuprofen (Duexis®)CYP2C9
CardiologyCalcium Channel BlockersFelodipine (Plendil®)CYP3A4
cardiologyAntilipemic AgentFenofibrate (Tricor®)APOE
Pain ManagementOpioidsFentanyl (Duragesic®)CYP3A4
UrologyAnticholinergic AgentFesoterodine (Toviaz®)CYP2D6
CardiologyAntiarrhythmic DrugsFlecainide (Tambocor®)CYP2D6
GynecologyMixed 5-HT1A Agonist/5-HT2A AntagonistFlibanserin (Addyi®)CYP2C19
OncologyAntimetabolite (Pyrimidine Analog)Fluorouracil (Carac®)ABCB1
OncologyAntimetabolite (Pyrimidine Analog)Fluorouracil (Carac®)DPYD
OncologyAntimetabolite (Pyrimidine Analog)Fluorouracil (Carac®)ERCC1
OncologyAntimetabolite (Pyrimidine Analog)Fluorouracil (Carac®)GSTP1
OncologyAntimetabolite (Pyrimidine Analog)Fluorouracil (Carac®)MTHFR
OncologyAntimetabolite (Pyrimidine Analog)Fluorouracil (Carac®)NQO1
OncologyAntimetabolite (Pyrimidine Analog)Fluorouracil (Carac®)XRCC1
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Fluoxetine (Prozac®)CYP2D6
PsychologyAntipsychotic AgentFluphenazineCYP1A2
RheumatologyNonsteroidal Antiinflammatory Drugs (NSAIDs)Flurbiprofen (Ansaid®)CYP2C9
CardiologyAntilipemic AgentFluvastatin (Lescol®)ACE
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Fluvoxamine (Luvox®)CYP2D6
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Fluvoxamine (Luvox®)HTR1A
SupplementsVitaminFolic AcidMTHFR
CardiologyDiureticsFurosemide (Lasix®)ACE
NeurologyAcetylcholinesterase InhibitorGalantamine (Razadyne®)CYP2D6
OncologyEGFR Tyrosine Kinase InhibitorGefitinib (Iressa®)CYP3A4
EndocrinologySulfonylureasGlimepiride (Amaryl®)G6PD
EndocrinologySulfonylurea/ThiazolidinedioneGlimepiride/Pioglitazone (Duetact®)CYP2C8
EndocrinologySulfonylurea/ThiazolidinedioneGlimepiride/Pioglitazone (Duetact®)G6PD
EndocrinologySulfonylureasGlipizide (Glucotrol®)G6PD
EndocrinologySulfonylureasGlyburide (Glynase®)G6PD
OncologyAntiemetic (Selective 5-HT3 Receptor Antagonist)Granisetron (Sancuso®)NOS1AP
PsychologyAntipsychoticsHaloperidol (Haldol®)CYP2D6
CardiologyVasodilatorHydralazineNAT2
CardiologyVasodilatorHydralazine/Isosorbide (Bidil®)NAT2
CardiologyDiureticsHydrochlorothiazide (Microzide®)ACE
CardiologyDiureticsHydrochlorothiazide (Microzide®)AGTR1
Pain ManagementOpioidsHydrocodone/acetaminophen (Vicodin®)CYP2D6
Pain ManagementOpioidsHydrocodone/acetaminophen (Vicodin®)CYP3A4
Pain ManagementOpioidsHydrocodone/acetaminophen (Vicodin®)OPRM1
RespiratoryAntitussive AgentHydrocodone/Chlorpheniramine (Tussicaps®)CYP3A4
RespiratoryAntitussive AgentHydrocodone/Chlorpheniramine (Tussicaps®)OPRM1
RespiratoryAntitussive AgentHydrocodone/Chlorpheniramine (Tussicaps®)CYP2D6
Pain ManagementOpioidsHydrocodone/Ibuprofen(Vicoprofen®)CYP3A4
Pain ManagementOpioidsHydrocodone/Ibuprofen(Vicoprofen®)CYP3A4
Pain ManagementOpioidsHydrocodone/Ibuprofen(Vicoprofen®)OPRM1
Pain ManagementOpioidsHydromorphone (Dilaudid®)OPRM1
Pain ManagementNonsteroidal Antiinflammatory Drugs (NSAIDs)Ibuprofen (Advil®)CYP2C9
OncologyTopoisomerase II InhibitorIdarubicin (Idamycin®)SCO1B1
PsychologyAntipsychoticsIloperidone (Fanapt®)CYP2D6
PsychologyTricyclic AntidepressantsImipramine (Tofranil®)CYP2C19
PsychologyTricyclic AntidepressantsImipramine (Tofranil®)CYP2D6
CardiologyAngiotensin II Receptor BlockersIrbesartan (Avapro®)ACE
CardiologyARBs/DiureticIrbesartan/HCTZ (Avalide®)ACE
CardiologyARBs/DiureticIrbesartan/HCTZ (Avalide®)AGTR1
OncologyTopoisomerase I InhibitorsIrinotecan (Camptosar®)UGT1A1
Infectious DiseasesAntitubercular AgentIsoniazidNAT2
CardiologyMiscellaneous Cardiovascular AgentIvabradine (Corlanor®)CYP3A4
AnesthesiologyGeneral AnestheticKetamine (Ketalar®)CYP2B6
Infectious DiseasesAntiretroviral DrugsLamivudine (Epivir®)ABCB1
NeurologyAnticonvulsant DrugsLamotrigine (Lamictal®)SCN2A
GastroenterologyProton Pump Inhibitors (PPIs)Lansoprazole (Prevacid®)CYP2C19
Infectious DiseasesAntihepaciviral DrugsLedipasvir/Sofosbuvir (Harvoni®)IFNL3
CardiologyCalcium Channel BlockersLercanidipine (Zanidip®)CYP3A4
RheumatologyAntigout AgentLesinurad (Zurampic®)CYP2C9
RheumatologyAntigout AgentLesinurad (Zurampic®)UGT1A1
OncologyChemotherapy Modulating AgentLeucovorin (Wellcovorin®)ERCC1
OncologyChemotherapy Modulating AgentLeucovorin (Wellcovorin®)GSTP1
OncologyChemotherapy Modulating AgentLeucovorin (Wellcovorin®)MTHFR
OncologyChemotherapy Modulating AgentLeucovorin (Wellcovorin®)XRCC1
PsychologySerotonin and Norepinephrine Reuptake Inhibitors (SNRIs)Levomilnacipran (Fetzima®)CYP3A4
AnesthesiologyLocal AnestheticLidocaine (Lidoderm®)CYP1A2
AnesthesiologyLocal AnestheticLidocaine/Prilocaine (Emla®)G6PD
NeurologyCNS Stimulants (ADHD)Lisdexamfetamine (Vyvanse®)COMT
CardiologyACE Inhibitors/DiureticLisinopril/HCTZ (Prinzide®)AGTR1
PsychologyAntimanic AgentsLithium (Lithobid®)ABCB1
Infectious DiseasesAntiretroviral DrugsLopinavir/Ritonavir(Kaletra®)ABCB1
PsychologyBenzodiazepinesLorazepam (Ativan®)UGT2B15
CardiologyAngiotensin II Receptor BlockersLosartan (Cozaar®)ABCB1
CardiologyAngiotensin II Receptor BlockersLosartan (Cozaar®)AGTR1
CardiologyARBs/DiureticLosartan/HCTZ (Hyzaar®)AGTR1
CardiologyARBs/DiureticLosartan/HCTZ (Hyzaar®)ABCB1
CardiologyAntilipemic AgentLovastatin (Mevacor®)CYP3A4
CardiologyAntilipemic AgentLovastatin (Mevacor®)CYP3A5
Infectious DiseasesTopical AntibioticMafenide (Sulfamylon®)G6PD
PsychologyTetracyclic AntidepressantsMaprotilineCYP2D6
Pain ManagementNonsteroidal Antiinflammatory Drugs (NSAIDs)Meloxicam (Mobic®)CYP2C9
OncologyAntimetabolite (Purine Analog)Mercaptopurine (Purinethol®)TPMT
EndocrinologyBiguanidesMetformin (Glucophage®)ATM
EndocrinologyBiguanide/ThiazolidinedioneMetformin/Pioglitazone (Actoplus Met®)CYP2C8
EndocrinologyBiguanide/ThiazolidinedioneMetformin/Pioglitazone (Actoplus Met®)ATM
Pain ManagementOpioidsMethadone (Methadose®)CYP2B6
Pain ManagementOpioidsMethadone (Methadose®)DRD2
Pain ManagementOpioidsMethadone (Methadose®)OPRM1
Pain ManagementOpioidsMethadone (Methadose®)CYP3A4
NeurologyCNS Stimulants (ADHD)Methamphetamine (Desoxyn®)FAAH
ImmunologyAntirheumatic ImmunosuppressantMethotrexate (Trexall®)ITPA
OncologyFolate AntimetaboliteMethotrexate (Trexall®)ABCB1
OncologyFolate AntimetaboliteMethotrexate (Trexall®)MTHFR
ToxicologyAntidoteMethylene Blue (Provayblue®)G6PD
NeurologyCNS Stimulants (ADHD)Methylphenidate (Ritalin)DRD1
NeurologyCNS Stimulants (ADHD)Methylphenidate (Ritalin®)CES1
NeurologyCNS Stimulants (ADHD)Methylphenidate (Ritalin®)COMT
ImmunologySystemic CorticosteroidMethylprednisolone (Medrol®)ABCB1
CardiologyBeta BlockerMetoprolol Tartrate (Lopressor®)CYP2D6
CardiologyBeta-Blocker/DiureticMetoprolol/HCTZ (Lopressor HCT®)CYP2D6
CardiologyBeta-Blocker/DiureticMetoprolol/HCTZ (Lopressor HCT®)AGTR1
PsychologyBenzodiazepinesMidazolam (Versed®)CYP3A5
NeurologySerotonin and Norepinephrine Reuptake Inhibitors (SNRIs)Milnacipran (Savella®)HTR1A
NeurologySerotonin and Norepinephrine Reuptake Inhibitors (SNRIs)Milnacipran (Savella®)ADRA2A
PsychologyAlpha-2 AntagonistMirtazapine (Remeron®)CYP2D6
Pain ManagementOpioidsMorphine (MS Contin ®)OPRM1
Pain ManagementOpioid, Opioid AntagonistMorphine/Naltrexone (Embeda®)OPRM1
Infectious DiseasesMiscellaneous AntibioticNalidixic Acid (Neggram®)G6PD
PsychologyOpioids AntagonistsNaloxone (Evzio®)OPRM1
PsychologyOpioids AntagonistsNaltrexone (Revia®)OPRM1
Pain ManagementNonsteroidal Antiinflammatory Drugs (NSAIDs)Naproxen (Aleve®)CYP2C9
NeurologyAntimigraine AgentNaproxen / Sumatriptan (Treximet®)CYP2C9
CardiologyBeta-BlockerNebivolol (Bystolic®)CYP2D6
Infectious DiseasesAntiretroviral DrugsNelfinavir (Viracept®)CYP2C19
Infectious DiseasesAntiretroviral DrugsNevirapine (Viramune®)CYP2B6
Infectious DiseasesAntiretroviral DrugsNevirapine (Viramune®)ABCB1
Smoking CessationSmoking Cessation AidNicotine (Nicoderm®)COMT
CardiologyCalcium Channel BlockersNifedipine (Adalat®)NOS1AP
OncologyBCR-ABL Tyrosine Kinase InhibitorNilotinib (Tasigna®)UGT1A1
CardiologyCalcium Channel BlockersNisoldipine (Sular®)CYP3A4
CardiologyCalcium Channel BlockersNitrendipine (Nitrepin®)AGTR1
CardiologyCalcium Channel BlockersNitrendipine (Nitrepin®)CYP3A4
Infectious DiseasesMiscellaneous AntibioticNitrofurantoin (Macrobid®)G6PD
CardiologyVasodilatorNitroprusside (Nitropress®)ACE
PsychologyTricyclic AntidepressantsNortriptyline (Pamelor®)CYP2C19
PsychologyTricyclic AntidepressantsNortriptyline (Pamelor®)CYP2D6
PsychologyAntipsychoticsOlanzapine (Zyprexa®)ANKK1
PsychologyAntipsychoticsOlanzapine (Zyprexa®)CYP1A2
PsychologyAntipsychoticsOlanzapine (Zyprexa®)HTR2C
Infectious DiseasesAntihepaciviral DrugsOmbitasvir/Paritaprevir/Ritonavir (Technivie®)IFNL3
GastroenterologyProton Pump Inhibitors (PPIs)Omeprazole (Prilosec®)CYP2C19
OncologyAntiemetic (Selective 5-HT3 Receptor Antagonist)Ondansetron (Zofran®)ABCB1
GynecologyHormonesOral-ContraceptivesF2
OncologyPlatinum AnalogOxaliplatin (Eloxatin®)ERCC1
OncologyPlatinum AnalogOxaliplatin (Eloxatin®)GSTP1
OncologyPlatinum AnalogOxaliplatin (Eloxatin®)MTHFR
OncologyPlatinum AnalogOxaliplatin (Eloxatin®)NQO1
OncologyPlatinum AnalogOxaliplatin (Eloxatin®)XRCC1
PsychologyBenzodiazepinesOxazepam (Serax®)UGT2B15
NeurologyAnticonvulsant DrugsOxcarbazepine (Trileptal®)SCN2A
Pain ManagementOpioidsOxycodone (Oxycontin®)CYP2D6
Pain ManagementOpioidsOxycodone (Oxycontin®)CYP3A4
Pain ManagementAnalgesicOxycodone/Acetaminophen (Percocet®)CYP2D6
Pain ManagementOpioid, Opioid AntagonistOxycodone/Naloxone (Targiniq ER®)CYP2D6
Pain ManagementOpioid, Opioid AntagonistOxycodone/Naloxone (Targiniq ER®)OPRM1
OncologyTaxane DerivativePaclitaxel (Abraxane®)ABCB1
OncologyTaxane DerivativePaclitaxel (Abraxane®)ERCC1
OncologyAntiemetic; Selective 5-HT3 Receptor AntagonistPalonosetron (Aloxi®)CYP2D6
GastroenterologyProton Pump Inhibitors (PPIs)Pantoprazole (Protonix®)CYP2C19
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Paroxetine (Paxil®)CYP2D6
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Paroxetine (Paxil®)HTR1A
OncologyBCR-ABL Tyrosine Kinase InhibitorPazopanib (Votrient®)UGT1A1
Infectious DiseasesAntihepaciviral DrugsPeginterferon alfa-2b (PegIntron®)IFNL3
Infectious DiseasesAntihepaciviral DrugsPeginterferon alfa-2b (PegIntron®)ITPA
ImmunologyUrate-Oxidase (Recombinent)Pegloticase (Krystexxa®)G6PD
OncologyFolate AntimetabolitePemetrexed (Alimta®)MTHFR
CardiologyACE InhibitorsPerindopril (Aceon®)ACE
CardiologyACE InhibitorsPerindopril (Aceon®)AGTR1
PsychologyAntipsychoticsPerphenazineCYP2D6
NeurologyAnticonvulsant DrugsPhenobarbitalABCB1
CardiologyAnticoagulantsPhenprocoumon (Marcoumar®)CYP4F2
NeurologyAnticonvulsant DrugsPhenytoin (Dilantin®)HLA-B
NeurologyAnticonvulsant DrugsPhenytoin (Dilantin®)SCN2A
PsychologyAntipsychoticsPimozide (Orap®)CYP2D6
EndocrinologyThiazolidinedionesPioglitazone (Actos®)CYP2C8
Pain ManagementNonsteroidal Antiinflammatory Drugs (NSAIDs)Piroxicam (Feldene®)CYP2C9
CardiologyAntilipemic AgentPitavastatin (Livalo®)SLCO1B1
CardiologyAntilipemic AgentPravastatin (Pravachol®)KIF6
CardiologyAntilipemic AgentPravastatin (Pravachol®)SLCO1B1
ImmunologySystemic CorticosteroidPrednisolone (Orapred®)ABCB1
ImmunologySystemic CorticosteroidPrednisone (Deltasone®)ABCB1
Infectious DiseasesAntimalarial DrugPrimaquine Phosphate (Primaquine®)G6PD
ImmunologyUricosuric AgentProbenecidG6PD
RespiratoryAntitussive AgentPromethazine and Dextromethorphan (Promethazine DM®)CYP2D6
CardiologyAntiarrhythmic DrugsPropafenone (Rythmol®)CYP2D6
AnesthesiologyGeneral AnestheticPropofol (Diprivan®)CYP2B6
CardiologyBeta-BlockerPropranolol (Inderal LA®)CYP2D6
PsychologyTricyclic AntidepressantsProtriptyline (Vivactil®)CYP2C19
PsychologyTricyclic AntidepressantsProtriptyline (Vivactil®)CYP2D6
Infectious DiseasesAntitubercular AgentPyrazinamide (Rifater®)NAT2
OncologyAntimetabolite (Pyrimidine Analog)Pyrimidinedione (Tegafur-Uracil®)DPYD
PsychologyAntipsychotic AgentQuetiapine (Seroquel®)SLC6A4
PsychologyAntipsychotic AgentQuetiapine (Seroquel®)FAAH
CardiologyACE InhibitorsQuinapril (Accupril®)ACE
CardiologyACE Inhibitors/DiureticQuinapril/HCTZ (Accuretic®)ACE
CardiologyACE Inhibitors/DiureticQuinapril/HCTZ (Accuretic®)AGTR1
Infectious DiseasesAntimalarial DrugQuinine (Qualaquin®)G6PD
GastroenterologyProton Pump Inhibitors (PPIs)Rabeprazole (Aciphex®)CYP2C19
OsteoporosisSelective Estrogen Receptor Modulator (SERM)Raloxifene (Evista®)UGT1A1
CardiologyAntianginal DrugsRanolazine (Ranexa)CYP2D6
OncologyUrate-Oxidase (Recombinant)Rasburicase (Elitek®)G6PD
PsychologySerotonin and Norepinephrine Reuptake Inhibitors (SNRIs)Reboxetine (Edronax®)CYP3A4
Infectious DiseasesAntihepaciviral DrugsRibavirin (Copegus®)IFNL3
Infectious DiseasesAntihepaciviral DrugsRibavirin (Copegus®)ITPA
Infectious DiseasesAntitubercular AgentRifampin (Rifadin®)NAT2
Infectious DiseasesAntitubercular AgentRifampin/Isoniazid (Rifamate®)NAT2
Infectious DiseasesAntitubercular AgentRifampin/Isoniazid/Pyrazinamide (Rifater®)NAT2
PsychologyAntipsychoticsRisperidone (Risperdal®)ANKK1
PsychologyAntipsychoticsRisperidone (Risperdal®)CYP2D6
PsychologyAntipsychoticsRisperidone (Risperdal®)DRD2
PsychologyAntipsychoticsRisperidone (Risperdal®)HTR2C
Infectious DiseasesAntiretroviral DrugsRitonavir (Norvir®)UGT1A1
CardiologyAnticoagulantsRivaroxaban (Xarelto®)CYP3A4
AnesthesiologyLocal AnestheticRopivacaine (Naropin®)CYP1A2
EndocrinologyThiazolidinedionesRosiglitazone (Avandia®)CYP2C8
CardiologyAntilipemic AgentRosuvastatin (Crestor®)SLCO1B1
OncologyEGFR Tyrosine Kinase InhibitorRuxolitinib (Jakavi®)CYP3A4
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Sertraline (Zoloft®)CYP2C19
UrologyAlpha 1 BlockerSilodosin (Rapaflo®)CYP3A4
Infectious DiseasesAntihepaciviral DrugsSimeprevir (Olysio®)IFNL3
CardiologyAntilipemic AgentSimvastatin (Zocor®)ABCB1
CardiologyAntilipemic AgentSimvastatin (Zocor®)CYP3A4
CardiologyAntilipemic AgentSimvastatin (Zocor®)CYP3A5
CardiologyAntilipemic AgentSimvastatin (Zocor®)SLCO1B1
CardiologyAntilipemic AgentSimvastatin/Ezetimibe (Vytorin®)ABCB1
CardiologyAntilipemic AgentSimvastatin/Ezetimibe (Vytorin®)SLCO1B1
ImmunologyImmunosuppressant AgentSirolimus (Rapamune®)CYP3A4
ImmunologyImmunosuppressant AgentSirolimus (Rapamune®)CYP3A5
ToxicologyAntidoteSodium NitriteG6PD
Infectious DiseasesAntihepaciviral DrugsSofosbuvir and Velpatasvir (Epclusa®)IFNL3
OncologyVEGF Tyrosine Kinase InhibitorSorafenib (NexAvar®)UGT1A1
CardiologyDiureticsSpironolactone (Aldactone®)ACE
CardiologyDiureticsSpironolactone/HCTZ (Aldactazide®)AGTR1
CardiologyDiureticsSpironolactone/HCTZ (Aldactazide®)ACE
Pain ManagementOpioidsSufentanil (Sufenta®)CYP3A4
Infectious DiseasesMiscellaneous AntibioticSulfamethoxazole/Trimethoprim (Bactrim®)G6PD
Immunology5-Aminosalicylic Acid DerivativeSulfasalazine (Azulfidine®)G6PD
OncologyVEGF Tyrosine Kinase InhibitorSunitinib (Sutent®)CYP3A4
ImmunologyImmunosuppressant AgentTacrolimus (Prograf®)CYP3A5
OncologySelective Estrogen Receptor Modulator (SERM)Tamoxifen (Soltamox®)CYP2D6
OncologySelective Estrogen Receptor Modulator (SERM)Tamoxifen (Soltamox®)F2
UrologyAlpha 1 BlockerTamsulosin (Flomax®)CYP2D6
Infectious DiseasesAntihepaciviral DrugsTelaprevir (Incivo®)IFNL3
Infectious DiseasesAntihepaciviral DrugsTelaprevir (Incivo®)ITPA
NeurologyCentral Monoamine-Depleting AgentTetrabenazine (Xenazine®)CYP2D6
OncologyImmunomodulatorsThalidomide (Thalomid®)ERCC1
OncologyAntimetabolite (Purine Analog)Thioguanine (Tabloid®)TPMT
PsychologyAntipsychoticsThioridazine (Mellaril®)CYP2D6
CardiologyAntiplateletsTicagrelor (Brilinta®)CYP3A4
Pain ManagementAlpha2-Adrenergic AgonistTizanidine (Zanaflex®)CYP1A2
EndocrinologySulfonylureasTolbutamideG6PD
UrologyAnticholinergic AgentTolterodine (Detrol®)CYP2D6
NeurologyAnticonvulsant DrugsTopiramate (Topamax®)SCN2A
CardiologyDiureticsTorsemide (Demadex®)ACE
Pain ManagementOpioidsTramadol (Ultram®)CYP2D6
Pain ManagementOpioidsTramadol hydrochloride/Acetaminophen (Ultracet®)CYP2D6
PsychologySerotonin Reuptake Inhibitor/AntagonistTrazodone (Desyrel®)CYP3A4
PsychologyTricyclic AntidepressantsTrimipramine (Surmontil®)CYP2C19
PsychologyTricyclic AntidepressantsTrimipramine (Surmontil®)CYP2D6
PsychologyAntipsychoticsValproic acid (Depakote®)ANKK1
PsychologySerotonin and Norepinephrine Reuptake Inhibitors (SNRIs)Venlafaxine (Effexor®)CYP2D6
CardiologyCalcium Channel BlockersVerapamil (Calan®)NOS1AP
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Vilazodone (Viibryd®)CYP3A4
OncologyVinca AlkaloidsVincristine (Marqibo®)ABCB1
Infectious DiseasesAntifungal DrugsVoriconazole (Vfend®)CYP2C19
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Vortioxetine (Trintellix®®)CYP2D6
CardiologyAnticoagulantsWarfarin (Coumadin®)CYP2C9
CardiologyAnticoagulantsWarfarin (Coumadin®)VKORC1
Infectious DiseasesAntiretroviral DrugsZidovudine(Retrovir®)ABCB1
NeurologyAntimigraine AgentZolmitriptan (Zomig®)CYP3A4
PsychologySelective Serotonin Reuptake Inhibitors (SSRIs)Sertraline (Zoloft®)HTR1A
CardiologyAntilipemic AgentRosuvastatin (Crestor®)CYP3A5
CardiologyAntiplateletsTicagrelor (Brilinta®)CYP2C19
CardiologyPhosphodiesterase InhibitorsCilostazol (Pletal®)CYP3A5
ImmunologyImmunosuppressant AgentCyclosporine (Gengraf®)CYP3A5
NeurologyAntimigraine AgentZolmitriptan (Zomig®)CYP1A2
OncologyAntiemetic (Selective 5-HT3 Receptor Antagonist)Dolasetron (Anzemet®)CYP2D6
OncologyAntiemetic (Selective 5-HT3 Receptor Antagonist)Granisetron (Sancuso®)CYP2D6
OncologyAntiemetic (Selective 5-HT3 Receptor Antagonist)Ondansetron (Zofran®)CYP2D6
PsychologyAntipsychoticsOlanzapine (Zyprexa®)SLC6A4
ImmunologyImmunosuppressant AgentTacrolimus (Prograf®)CYP3A4
Pain ManagementOpioidsFentanyl (Duragesic®)OPRM1
PsychologyAntipsychoticsClozapine (Clozaril®)CYP1A2
PsychologyAntipsychoticsRisperidone (Risperdal®)SLC6A4

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Included with PGxOne™ Plus Report
Drug interactions for a patient’s current medications

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Drug to Drug

Drug interactions can result
in adverse side effects,
reduce the effectiveness or
increase drug activity

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Drug to Food

Food consumption can
affect the activity of some
drugs, altering efficacy

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Drug to Lab

Some laboratory test results
can be misleading. Certain
medications can falsely elevate
a lab test, resulting in a false
positive

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Drug to Alcohol

Alcohol does interact with
some medications and can lead
to increased risk of illness,
injury, or death

The level of severity of drug interactions is reported out at three levels with warnings, level of documentation, and clinical management recommendations

severity_report_icons_key2 PGxOne™ Plus

Included with PGxOne™ Plus Report
Drug interactions for a patient’s current medications

drug_by_drug_icon PGxOne™ Plus

Drug to Drug

Drug interactions can result in adverse side effects, reduce the effectiveness or increase drug activity

Drug_to_Food_icon PGxOne™ Plus

Drug to Food

Food consumption can affect the activity of some drugs, altering efficacy

Drug_to_lab_icon PGxOne™ Plus

Drug to Lab

Some laboratory test results can be misleading. Certain medications can falsely elevate a lab test, resulting in a false positive

Drug_To_alcohol_icon PGxOne™ Plus

Drug to Alcohol

Alcohol does interact with some medications and can lead to increased risk of illness, injury, or death

The level of severity of drug interactions is reported out at three levels with warnings, level of documentation and clinical management recommendations

severity_report_icons_key2 PGxOne™ Plus

Sample Collection

Our video walks you through our easy 3-step process for proper sample collection. This will reduce the need for resampling and yield accurate test results.

Sample Collection

Our video walks you through our easy 3-step process for proper sample collection. This will reduce the need for resampling and yield accurate test results.

Depending on need, Admera Health offers a suite of PGxOne™ Plus reports:

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Genetic testing for
optimizing psychiatric
drug therapy

Learn more
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Genetic testing for
optimizing cardiovascular
drug therapy

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Genetic testing for optimizing supportive care drug therapy for cancer patients

Learn more