Are Your Medications On Target?
PGxOne™ Plus is a pharmacogenomics (PGx) test ordered by a healthcare provider, that combines the study of genetics with the study of drug delivery. Test results provide additional insight into how you may respond to certain medications.
A more personalized approach to medication management that reduces trial and error prescribing may help with:
- Increasing the chances of therapeutic success
- Reducing adverse reactions to drugs
In addition to PGx, test results include drug interaction information for your current medications.
- Avoid harmful interactions or those that impair drug efficacy
- Drug-Drug, Drug-Food, Drug-Alcohol
- Receive more accurate laboratory results
Are Your Medications On Target?
PGxOne™ Plus is a pharmacogenomics (PGx) test ordered by a healthcare provider, that combines the study of genetics with the study of drug delivery. Test results provide additional insight into how you may respond to certain medications.
A more personalized approach to medication management that reduces trial and error prescribing may help with:
- Increasing the chances of therapeutic success
- Reducing adverse reactions to drugs
In addition to PGx, test results include drug interaction information for your current medications.
- Avoid harmful interactions or those that impair drug efficacy
- Drug-Drug, Drug-Food, Drug-Alcohol
- Receive more accurate laboratory results
What is Pharmacogenomics (PGx) Testing?
Liver enzymes are responsible for metabolizing some inactive drugs into their active forms, as well as metabolizing active drugs into inactive forms.
Specific variants in your DNA can impact these enzymes, making them metabolize drugs too fast, too slow, or not at all. These impaired enzymes may lead to drugs not working as expected or possibly even being harmful.
Normal Metabolizer
Poor Metabolizer
Intermediate Metabolizer
Ultrarapid Metabolizer
Transporters and Channels
Other DNA variants can result in changes to cell transporters and channels, impacting the movement of drugs within your body.
Transporter Proteins
Transporter proteins facilitate selective transfer of molecules across biomembranes (e.g. the blood–brain barrier) and can be crucial to a drug’s ability to reach the effect site. Channel proteins and carrier proteins are two types of transporter proteins.
Channel Proteins
Channel proteins have a tunnel that allows specifically charged ions to pass through the cell
Carrier Proteins
Carrier proteins alter shape to move specific molecules through the cell
DNA variants can impact the effect a drug could have on your body too. For example, DNA variations can result in changes to drug targets.
Why Get PGx Testing Done?
- To have a more personalized approach to managing your medications
- If you are taking multiple medications, risks for adverse reactions go up with the more drugs you are taking
- For certain drugs it is required or recommended to have PGx testing done before taking them
- When you have had an adverse reaction or complication to a medication
- There is a family history of a serious adverse drug reaction or known pharmacogenomic variant
- If it is suspected you may require a higher or lower than the standard dose of a medication
- If your treatment is not working as expected or has failed
- PGx testing can be done preemptively so results are available when needed
