Atrial fibrillation (AF) is a common heart arrhythmia in the general population with prevalence increasing with age affecting nearly 6% of individuals over 65 years. There are many cardiac conditions that may predispose to the development of this arrhythmia, although it was observed in the recent years that genetics may be the cause in 5%-15% of cases diagnosed with lone AF.
Patients with a family history of atrial fibrillation in the absence of predisposing factors such as hypertension, ischemic cardiomyopathy, structural or organic heart diseases.
Atrial Fibrillation Panel
The panel includes genes with clinical and functional evidence of association with familial atrial fibrillation. Many of the included genes are associated with defined electrophysiological phenotypes or even structural heart diseases in which the development of atrial fibrillation may be the first or the main manifestation of the disease.
ABCC9, ACTC1, EMD, GATA4, GATA6, GJA1, GJA5, HCN4, KCNA5, KCND3, KCNE1, KCNE1L, KCNE2, KCNE3, KCNJ2, KCNQ1, LMNA, NKX2-5, NPPA, PITX2, RYR2, SCN10A, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A, TBX5, TTR, CACNB2*, JPH2*, KCNH2*, KCNJ5*, KCNJ8*, KCNK3*, TNNI3*, TNNT2*, TPM1*