Arrhythmias General Panel
LQTS, SQTS, BS, CPVT, CCD, ARVD/C, HCM, DCM.
This panel is mainly aimed at the diagnosis of cases where it is not possible to establish a clearly defined phenotype, but where cardiac arrhythmias are the main manifestation.
It is mainly intended for subjects with personal or familial history of sudden death with unknown origin or subjects with ventricular fibrillation of unknown origin that meet the above-mentioned characteristics.
It includes priority genes with a clear association with these diseases, secondary genes where the evidence is lower, and candidate genes gathered from a systematic literature review.
ACTC1, CACNA1C, CASQ2, DES, DSC2, DSG2, DSP, EMD, FLNC, GLA, JUP, KCNE1, KCNE2, KCNH2, KCNJ2, KCNQ1, LAMP2, LMNA, MYBPC3, MYH7, MYL2, MYL3, PKP2, PLN, PRKAG2, PTPN11, RYR2, SCN10A, SCN5A, TMEM43, TNNC1, TNNI3, TNNT2, TPM1, TTR, AARS2, ABCC9, ACAD9, ACADVL, ACTA1, ACTN2, AGK, AGL, AGPAT2, AKAP9, ANK2, ANKRD1, ATPAF2, BRAF, BSCL2, CACNA1D, CACNA2D1, CACNB2, CALM1, CALM2, CALR3, CAV3, COQ2, COX15, COX6B1, CRYAB, CSRP3, CTNNA3, DLD, FAH, FHL1, FHL2, FHOD3, GAA, GATA4, GATA6, GFM1, GJA1, GJA5, GLB1, GNPTAB, GPD1L, GUSB, HCN4, HFE, HRAS, JPH2, KCND3, KCNE1L, KCNE3, KCNJ5, KCNJ8, KCNK3, KRAS, LDB3, LIAS, MAP2K1, MAP2K2, MLYCD, MRPL3, MRPS22, MTO1, MURC, MYH6, MYOZ2, MYPN, NEXN, NKX2-5, NRAS, PDHA1, PHKA1, PMM2, RAF1, RANGRF, SCN1B, SCN2B, SCN3B, SCN4B, SHOC2, SLC22A5, SLC25A4, SLMAP, SNTA1, SOS1, SURF1, TAZ, TBX5, TCAP, TGFB3, TMEM70, TRDN, TRIM63, TRPM4, TSFM, TTN, VCL, ANK3*, BAG3*, CTF1*, KCNA5, KLF10*, MYLK2*, NPPA*, OBSL1*, PDLIM3*, PITX2*