PGxOne™ Plus Pharmacogenomics Test

PGxOne_Plus_logo_final_plus_updated PGxOne™ Plus

PGxOne™ Plus is a pharmacogenomics test that predicts how patients will respond to drug therapy based on their individual genetic makeup. Differences between individuals can affect drug absorption, metabolism, or activity. Therefore, while one treatment regimen may work well for one individual, the same regimen may cause adverse effects for other individuals.1, 2PGxOne™ Plus comprehensively screens 50 well-established pharmacogenomic genes in a single, cost-effective test that provides medically actionable and clinically relevant data, thus allowing physicians to make effective treatment decisions. Expanding beyond pharmacogenomics, PGxOne™ Plus reports potential adverse interactions of the patient’s current medications.

 
 

Clinical Interpretations

Metabolizer Phenotypes: Individuals with variants associated with elevated drug metabolism (ultra-fast metabolizers) can benefit from higher doses in order to achieve therapeutic effects. Other variants can result in poor drug metabolism and are associated with higher risk for toxicity.

Drug Absorption: Membrane transporters are crucial determinants of drug absorption. The genetic variability in the genes encoding these transporters has been linked to significant differences in the pharmacokinetics of drug absorption.

Drug Activity: Drug activity can also be affected by genetic variability associated with the biological drug targets.

 
 

Drugs by Clinical Specialty

Drug Class Drug Gene
Local Anesthetics Lidocaine (Lidoderm®) CYP1A2
Ropivacaine (Naropin®) CYP1A2
General Anesthetics Ketamine (Ketalar®) CYP2B6
Propofol (Diprivan®) CYP2B6
Sedative Dexmedetomidine (Precedex®) ADRA2A
Local Anesthetic Lidocaine and Prilocaine (Emla®) G6PD
Drug Class Drug Gene
ACE Inhibitors Benazepril (Lotensin®) ACE
Captopril (Capoten®) ACE
AGTR1
Perindopril (Aceon®) ACE
AGTR1
Quinapril (Accupril®) ACE
Angiotensin II Receptor Blockers Candesartan  (Atacand®) AGTR1
Irbesartan (Avapro®) ACE
Losartan (Cozaar®) ABCB1
AGTR1
Antianginal Agent Ranolazine (Ranexa®) CYP2D6
Antiarrhythmic Agent Amiodarone (Cordarone®) CYP3A4
NOS1AP
Digoxin (Lanoxin®) ABCB1
Dronedarone (Multaq®) CYP3A4
Flecainide (Tambocor®) CYP2D6
Propafenone (Rythmol®) CYP2D6
Anticoagulants Phenprocoumon (Marcoumar®) CYP4F2
Rivaroxaban (Xarelto®) CYP3A4
Warfarin (Coumadin®) CYP2C9
VKORC1
Antiplatelets Clopidogrel (Plavix®) CYP2C19
Ticagrelor (Brilinta®) CYP3A4
Beta Blockers Atenolol (Tenormin®) ADRA2A
Carvedilol (Coreg®) CYP2D6
Nebivolol (Bystolic®) CYP2D6
Propranolol (Inderal LA®) CYP2D6
Metoprolol Tartrate (Lopressor®) CYP2D6
Calcium Channel Blockers Amiodarone (Cordarone®) NOS1AP
Amlodipine (Norvasc®) CYP3A4
NOS1AP
Diltiazem (Cardizem®) CYP3A4
Felodipine (Plendil®) CYP3A4
Lercanidipine (Zanidip®) CYP3A4
Nifedipine (Adalat®) NOS1AP
Nisoldipine (Sular®) CYP3A4
Nitrendipine (Nitrepin®) AGTR1
CYP3A4
Verapamil (Calan®) NOS1AP
Diuretics Bumetanide (Bumex®) ACE
Furosemide (Lasix®) ACE
Hydrochlorothiazide (Microzide®) ACE
AGTR1
Spironolactone/HCTZ (Aldactazide®) ADTR1
ACE
Spironolactone (Aldactone®) ACE
Torasemide (Demadex®) ACE
Phosphodiesterase Inhibitors Cilostazol (Pletal®) CYP3A4
Antilipemic Agent Atorvastatin (Lipitor®) ABCB1
APOE
CYP3A4
CYP3A5
KIF6
SLCO1B1
Fluvastatin (Lescol®) ACE
Lovastatin (Mevacor®) CYP3A4
CYP3A5
Pitavastatin (Livalo®) SLCO1B1
Pravastatin (Pravachol®) KIF6
SLCO1B1
Rosuvastatin (Crestor®) SLCO1B1
Simvastatin (Zocor®) ABCB1
CYP3A4
CYP3A5
SLCO1B1
Atorvastatin/Ezetimibe (Liptruzet®) ABCB1
APOE
CYP3A4
KIF6
SLOC1B1
Fenofibrate (Tricor®) APOE
Simvastatin/Ezetimibe (Vytorin®) ABCB1
SLCO1B1
Vasodilators Nitroprusside (Nipride®) ACE
Hydralazine NAT2
Hydralazine/Isosorbide (Bidil®) NAT2
Miscellaneous Cardiovascular Agents Ivabradine (Corlanor®) CYP3A4
ACE Inhibitors/Diuretics Quinapril/HCTZ (Accuretic®) ACE
AGTR1
Captopril/HCTZ (Capozide®) ACE
AGTR1
Benazepril/HCTZ (Lotensin HCT®) ACE
AGTR1
Lisinopril/HCTZ (Prinzide®) AGTR1
Enalapril/HCTZ (Vaseretic®) AGTR1
ARBs/Diuretics Candesartan/HCTZ (Atacand HCT®) AGTR1
Irbesartan/HCTZ (Avalide®) ACE
AGTR1
Losartan/HCTZ (Hyzaar®) AGTR1
ABCB1
Beta-Blocker/Diuretic Metoprolol/HCTZ (Lopressor HCT®) CYP2D6
AGTR1
CCB/ACE Inhibitor Amlodipine/Benazepril (Lotrel®) ACE
CYP3A4
NO1SAP
Therapeutic Area Drug Class Drug Gene
Dentistry Cholinergic Agonists Cevimeline (Evoxac®) CYP2D6
Drug Class Drug Gene
Biguanides Metformin (Glucophage®) ATM
Biguanide/Thiazolidinedione Metformin/Pioglitazone (Actoplus Met®) CYP2C8
ATM
Endocrine Enzyme Inhibitor Eliglustat (Cerdelga®) CYP2D6
Sulfonylureas Chlorpropamide (Diabinese®) G6PD
Glimepiride (Amaryl®) G6PD
Glipizide (Glucotrol®) G6PD
Glyburide (Glynase®) G6PD
Tolbutamide (Orinase®) G6PD
Sulfonylurea/Thiazolidinedione Glimepiride/Pioglitazone (Duetact®) CYP2C8
G6PD
Thiazolidinediones Rosiglitazone (Avandia®) CYP2C8
Pioglitazone (Actos®) CYP2C8
Drug Class Drug Gene
Proton Pump Inhibitors (PPIs) Dexlansoprazole (Dexilant®) CYP2C19
Esomeprazole (Nexium®) CYP2C19
Lansoprazole (Prevacid®) CYP2C19
Omeprazole (Prilosec®) CYP2C19
Pantoprazole (Protonix®) CYP2C19
Rabeprazole (Aciphex®) CYP2C19
Osmotic Laxative Ascorbic Acid(Moviprep) G6PD
H2 Receptor Antagonist/NSAID Famotidine/Ibuprofen (Duexis®) CYP2C9
H2 Receptor Antagonist Famotidine (Pepcid®) CYP2C19
Drug Class Drug Gene
Contraceptives Oral-Contraceptive F2
Ethinyl Estradiol and Norelgestromin(Ortho Evra®) F5
Oral Contraceptive Ethinyl Estradiol/Drospirenone (Yaz®) CYP2C19
Mixed 5-HT1A Agonist/5-HT2A Antagonist Flibanserin (Addyi®) CYP2C19
Therapeutic Area Drug Class Drug Gene
Hematology Platelet Stimulating Agents Eltrombopag (Promacta®) F5
Drug Class Drug Gene
Antigout Agent Lesinurad (Zurampic®) CYP2C9
UGT1A1
Systemic Corticosteroids Methylprednisolone (Medrol®) ABCB1
Prednisolone (Orapred®) ABCB1
Prednisone (Deltasone®) ABCB1
Immunosuppressant Agents Azathioprine (Imuran®) TPMT
Cyclosporine (Gengraf) ABCB1
Sirolimus (Rapamune®) CYP3A5
CYP3A4
Tacrolimus (Prograf®) CYP3A5
Antirheumatic Immunosuppressant Methotrexate (Trexall®) ITPA
Urate-Oxidase (Recombinent)/Uricosuric Agent Pegloticase (Krystexxa®) G6PD
Probenecid (Probalan®) G6PD
Xanthine Oxidase Inhibitors Allopurinol (Zyloprim®) HLA-B
5-Aminosalicylic Acid Derivative Sulfasalazine (Azulfidine®) G6PD
Drug Class Drug Gene
Antitubercular Agent Isoniazid NAT2
Pyrazinamide (Rifater®) NAT2
Ethambutol (Myambutol®) NAT2
Rifampin/Isoniazid (Rifamate®) NAT2
Rifampin/Isoniazid/Pyrazinamide (Rifater®) NAT2
Rifampin (Rifadin®) NAT2
Antifungal Drugs Voriconazole (Vfend®) CYP2C19
Antimalarial Drugs Chloroquine (Aralen®) G6PD
Quinine (Qualaquin®) G6PD
Primaquine Phosphate (Primaquine®) G6PD
Antiretroviral Drugs Abacavir (Ziagen®) HLA-B
Efavirenz (Sustiva)®) CYP2B6
Abacavir and Lamivudine (Epzicom) HLA-B
Nevirapine (Viramune®) CYP2B6
ABCB1
Abacavir, Lamivudine, and Zidovudine (Trizivir) HLA-B
Efavirenz / Emtricitabine / Tenofovir (Atripla®) CYP2B6
Nelfinavir (Viracept®) CYP2C19
Abacavir, Dolutegravir, and Lamivudine (Triumeq®) UGT1A1
HLA-B
Dolutegravir (Tivicay®) UGT1A1
Zidovudine(Retrovir®) ABCB1
Lamivudine (Epivir®) ABCB1
Lopinavir/Ritonavir(Kaletra®) ABCB1
Ritonavir (Norvir®) UGT1A1
Atazanavir (Reyataz®) UGT1A1
Antihepaciviral Drugs Telaprevir (Incivek®) ITPA
IFNL3
Peginterferon alfa-2b (PegIntron®) IFNL3
ITPA
Ribavirin (Copegus®) IFNL3
ITPA
Boceprevir (Victrelis®) IFNL3
ITPA
Simeprevir (Olysio®) IFNL3
Daclatasvir (Daklinza®) IFNL3
Ledipasvir/Sofosbuvir (Harvoni®) IFNL3
Ombitasvir/Paritaprevir/Ritonavir (Technivie®) IFNL3
Elbasvir and Grazoprevir (Zepatier®) IFNL3
Sofosbuvir and Velpatasvir (Epclusa®) IFNL3
Miscellaneous Antibiotics Dapsone G6PD
Nitrofurantoin (Macrobid®) G6PD
Sulfamethoxazole/Trimethoprim (Bactrim®) G6PD
Macrolides Erythromycin/sulfisoxazole (Pediazole®) G6PD
Lipopeptide Daptomycin (Cubicin®) ABCB1
Topical Antibiotic Mafenide (Sulfamylon®) G6PD
Drug Class Drug Gene
Anticonvulsant Drugs Carbamazepine (Tegretol®) HLA-B
SCN2A
Lamotrigine (Lamictal®) SCN2A
Oxcarbazepine (Trileptal®) SCN2A
Phenytoin (Dilantin®) HLA-B
SCN2A
Brivaracetam (Briviact®) CYP2C19
Clobazam (Onfi®) CYP2C19
Valproic Acid (Depakote®) ANKK1
Phenobarbital ABCB1
Topiramate (Topamax®) SCN2A
COMT Inhibitors Entacapone (Comtan®) COMT
Antimigraine Agent Eletriptan (Relpax®) CYP3A4
Zolmitriptan (Zomig®) CYP3A4
Naproxen / Sumatriptan (Treximet®) CYP2C9
Acetylcholinesterase Inhibitor Donepezil (Aricept®) CYP2D6
Galantamine (Razadyne®) CYP2D6
NMDA Receptor Antagonist Dextromethorphan and Quinidine(Nuedexta®) CYP2D6
Central Monoamine-Depleting Agent Tetrabenazine (Xenazine®) CYP2D6
Drug Class Drug Gene
Taxane Derivative Paclitaxel (Abraxane®) ABCB1
ERCC1
Docetaxel (Taxotere®) ERCC1
Cabazitaxel (Jevtana®) CYP3A4
Antimetabolite (Pyrimidine Analog) Fluorouracil (Carac®) ABCB1
DPYD
ERCC1
GSTP1
MTHFR
NQO1
XRCC1
Capecitabine (Xeloda®) DPYD
Antimetabolite (Folate) Methotrexate (Trexall®) ABCB1
MTHFR
Pemetrexed (Alimta®) MTHFR
Antimetabolite (Purine Analog) Mercaptopurine (Purinethol®) TPMT
Thioguanine (Tabloid®) TPMT
Platinum Analog Carboplatin (Paraplatin®) ERCC1
GSTP1
MTHFR
XRCC1
Oxaliplatin (Eloxatin®) ERCC1
GSTP1
MTHFR
NQO1
XRCC1
Cisplatin (Platinol®) ERCC1
GSTP1
NQO1
XRCC1
Alkylating Agent Cyclophosphamide (Cytoxan®) GSTP1
MTHFR
NQO1
Anthracycline Doxorubicin (Doxil®) ABCB1
NQO1
Epirubicin (Ellence®) GSTP1
NQO1
Chemotherapy Modulating Agent Leucovorin (Wellcovorin®) ERCC1
GSTP1
MTHFR
XRCC1
Urate-Oxidase (Recombinant) Rasburicase (Elitek®) G6PD
Selective Estrogen Receptor Modulator (SERM) Tamoxifen (Soltamox®) CYP2D6
F2
Raloxifene (Evista®) UGT1A1
BRAF Kinase Inhibitor Dabrafenib (Tafinlar®) G6PD
EGFR Tyrosine Kinase Inhibitor Erlotinib (Tarceva®) UGT1A1
Ruxolitinib (Jakavi®) CYP3A4
Gefitinib (Iressa®) CYP3A4
BCR-ABL Tyrosine Kinase Inhibitor Nilotinib (Tasigna®) UGT1A1
Pazopanib (Votrient®) UGT1A1
VEGF Tyrosine Kinase Inhibitor Sorafenib (NexAvar®) UGT1A1
Sunitinib (Sutent®) CYP3A4
Antiemetic (Selective 5-HT3 Receptor Antagonist) Dolasetron (Anzemet®) NOS1AP
Granisetron (Sancuso®) NOS1AP
Palonosetron (Aloxi®) CYP2D6
Ondansetron (Zofran®) ABCB1
Antiemetic (Corticosteroid) Dexamethasone (Decadron®) ABCB1
Topoisomerase I Inhibitors Irinotecan (Camptosar®) UGT1A1
Immunomodulators Thalidomide (Thalomid®) ERCC1
Vinca Alkaloids Vincristine (Marqibo®) ABCB1
Histone Deacetylase (HDAC) Inhibitor Belinostat (Beleodaq) UGT1A1
Antiemetic; Appetite Stimulant Dronabinol (Marinol®) CYP2C9
Topoisomerase II Inhibitor Idarubicin (Idamycin®) SCO1B1
Therapeutic Area Drug Class Drug Gene
Ophthalmology Nonsteroidal Antiinflammatory Drugs (NSAIDs) Flurbiprofen (Ocufen®) CYP2C9
Drug Class Drug Gene
Central Alpha-2 Adrenergic Agonists Tizanidine (Zanaflex®) CYP1A2
Skeletal Muscle Relaxants Carisoprodol (Soma®) CYP2C19
Cyclobenzaprine (Flexeril®) CYP1A2
Nonsteroidal Antiinflammatory Drugs (NSAIDs) Celecoxib (Celebrex®) CYP2C9
Diclofenac (Voltaren®) CYP2C9
Ibuprofen (Advil®) CYP2C9
Meloxicam (Mobic®) CYP2C9
Naproxen (Aleve®) CYP2C9
Piroxicam (Feldene®) CYP2C9
Opioids Alfentanil (Alfenta®) OPRM1
Buprenorphine (Subutex®) CYP3A4
Codeine (Codeine®) CYP2D6
CYP3A4
Codeine/Acetaminophen (Tylenol #3, #4®) CYP2D6
Fentanyl (Duragesic®) CYP3A4
Hydrocodone/Acetaminophen (Vicodin®) CYP2D6
CYP3A4
OPRM1
Hydrocodone/Ibuprofen(Vicoprofen®) CYP2C9
OPRM1
CYP3A4
Hydromorphone (Dilaudid®) OPRM1
Methadone (Methadose®) CYP3A4
CYP2B6
DRD2
OPRM1
Morphine (MS Contin®) OPRM1
Morphine/Naltrexone (Embeda®) OPRM1
Oxycodone (Oxycontin®) CYP2D6
CYP3A4
Oxycodone/Acetaminophen (Percocet®) CYP2D6
Oxycodone/Naloxone (Targiniq ER®) CYP2D6
OPRM1
Sufentanil (Sufenta®) CYP3A4
Tramadol (Ultram®) CYP2D6
Tramadol hydrochloride/Acetaminophen (Ultracet®) CYP2D6
Drug Class Drug Gene
Antimanic Agents Lithium (Lithane®) ABCB1
Antipsychotic Agents Aripiprazole (Abilify®) CYP2D6
CYP3A4
Brexpiprazole (Rexulti®) CYP2D6
Clozapine (Clozaril®) ANKK1
CYP2D6
HTR2C
Haloperidol (Haldol®) CYP2D6
Iloperidone (Fanapt®) CYP2D6
Olanzapine (Zalasta®) ANKK1
CYP1A2
HTR2C
Perphenazine (Trilafon®) CYP2D6
Pimozide (Orap®) CYP2D6
Risperidone (Risperdal®) ANKK1
CYP2D6
DRD2
HTR2C
Thioridazine (Mellaril®) CYP2D6
Chlorpromazine CYP1A2
Fluphenazine CYP1A2
Quetiapine (Seroquel®) FAAH
SLC6A4
Aldehyde Dehydrogenase Inhibitor Disulfiram (Antabuse®) ANKK1
Alpha-2 Antagonist Mirtazapine (Remeron®) CYP2D6
Anti-anxiety Agent Buspirone (Buspar®) HTR1A
Benzodiazepines Alprazolam (Xanax®) CYP3A4
Diazepam (Valium®) CYP2C19
Lorazepam (Ativan®) UGT2B15
Midazolam (Versed®) CYP3A5
Oxazepam (Serax®) UGT2B15
Opioid Antagonists Naloxone (Evzio®) OPRM1
Naltrexone (Revia®) OPRM1
Buprenorphine/Naloxone (Suboxone®) CYP3A4
OPRM1
Selective Serotonin Reuptake Inhibitors (SSRIs) Citalopram (Celexa®) CYP2C19
GRIK4
HTR2A
SLC6A4
Escitalopram (Lexapro®) CYP2C19
SLC6A4
Fluoxetine (Prozac®) CYP2D6
Fluvoxamine (Luvox®) CYP2D6
HTR1A
Paroxetine (Paxil®) CYP2D6
HTR1A
Sertraline (Zoloft®) CYP2C19
Vilazodone (Viibryd®) CYP3A4
Vortioxetine (Trintellix®) CYP2D6
Selective Norepinephrine Reuptake Inhibitors (SNRIs) Duloxetine (Cymbalta®) CYP1A2
Nefazodone ABCB1
Levomilnacipran (Fetzima®) CYP3A4
Milnacipran (Savella®) ADRA2A
HTR1A
Reboxetine (Edronax®) CYP3A4
Trazodone (Desyrel®) CYP3A4
Venlafaxine (Effexor®) CYP2D6
CNS Stimulants Dextroamphetamine and Amphetamine (Adderall®) COMT
DRD1
OPRM1
Cannabinoids FAAH
Cocaine CNR1
Dexmethylphenidate (Focalin®) COMT
Lisdexamfetamine (Vyvanse®) COMT
Methamphetamine (Desoxyn®) FAAH
Methylphenidate (Ritalin®) CES1
COMT
DRD1
SNRI (ADHD) Atomoxetine (Strattera®) CYP2D6
Tetracyclic Antidepressants Maprotiline (Ludiomil®) CYP2D6
Tricyclic Antidepressants Amitriptyline (Elavil®) CYP2C19
CYP2D6
Clomipramine (Anafranil®) CYP2C19
CYP2D6
Desipramine (Norpramin®) CYP2C19
CYP2D6
Doxepin (Silenor®) CYP2C19
CYP2D6
Imipramine (Tofranil®) CYP2C19
CYP2D6
Nortriptyline (Pamelor®) CYP2C19
CYP2D6
Protriptyline (Vivactil®) CYP2C19
CYP2D6
Trimipramine (Surmontil®) CYP2C19
CYP2D6
Drug Class Drug Gene
Antitussive Agent Hydrocodone/Chlorpheniramine (Tussicaps®) CYP3A4
OPRM1
CYP2D6
Promethazine and Dextromethorphan (Promethazine DM®) CYP2D6
Therapeutic Area Drug Class Drug Gene
Smoking Cessation Smoking Cessation Aid Nicotine (Nicoderm®) COMT
Bupropion (Zyban®) ANKK1
Therapeutic Area Drug Class Drug Gene
Supplements Vitamin Folic Acid MTHFR
Drug Class Drug Gene
Antidote Ethanol ANKK1
OPRM1
Methylene Blue (Provayblue®) G6PD
Sodium Nitrite G6PD
Drug Class Drug Gene
Alpha 1 Blockers Dutasteride/Tamsulosin (Jalyn®) CYP2D6
Silodosin (Rapaflo®) CYP3A4
Tamsulosin (Flomax®) CYP2D6
Anticholinergic Agent Darifenacin (Enablex®) CYP2D6
Tolterodine (Detrol®) CYP2D6
Fesoterodine (Toviaz®) CYP2D6
Therapeutic Area Drug Class Drug Gene
Weight Management Anorexiant Bupropion/Naltrexone (Contrave®) ANKK1
OPRM1
 
 

PGxOne™ Genes Assayed

ABCB1 ACE ADRA2A AGTR1 ANKK1
COMT CYP1A2 CYP2B6 CYP2C19 CYP2C8
DPYD DRD1 DRD2 ERCC1 F2
HLA-B HTR1A HTR2A HTR2C IFNL3
NQO1 OPRM1 SCN2A SLC6A4 SLCO1B1
APOE ATM CDA CES1 CNR1
CYP2C9 CYP2D6 CYP3A4 CYP3A5 CYP4F2
F5 FAAH G6PD GRIK4 GSTP1
ITPA KIF6 MTHFR NAT2 NOS1AP
TPMT UGT1A1 UGT2B15 VKORC1 XRCC1

Reports on Interactions

severity_report_icons_key2 PGxOne™ Plus

The level of severity of drug interactions is reported out at three levels with warnings, level of documentation and clinical management recommendations.

 
 

PGxOneTM Plus Sample Reports and Informational Sheet

Sample Submission Guidelines – PGxOneTM Plus

The following video will review proper techniques for collecting a buccal or cheek swab sample for processing in our laboratory in three easy steps. This will reduce the need for resample and is critical to yield good test results.

References

  1. Kitzmiller JP, Groen DK, Phelps MA, Sadee W. Pharmacogenomic testing: relevance in medical practice: why drugs work in some patients but not in others. Cleveland Clinic journal of medicine. 2011 Apr;78(4):243-57.
  2. Wang L, McLeod HL, Weinshilboum RM. Genomics and drug response. The New England journal of medicine. 2011 Mar 24;364(12):1144-53.